New Cyclopentadienyl, Indenyl or Fluorenyl Substituted Phosphine Compounds and their Use in Catalytic Reactions

ABSTRACT

Disclosed herein are phosphine compounds represented by the general formula (4): 
     
       
         
         
             
             
         
       
     
     and corresponding phosphonium salts represented by the general formula (4a): 
     
       
         
         
             
             
         
       
     
     Also disclosed are processes for the preparation of these phosphines and phosphonium salts as well as their use as ligands in catalytic reactions.

The present invention relates to new phosphine ligands, to their preparation and to their use in catalytic reactions, especially organic coupling reactions employing aryl, heteroaryl or vinyl halides and pseudohalides as educts.

Organic coupling reactions are an important tool to form carbon-carbon and carbon-heteroatom bonds. The popularity of coupling reactions is partly due to their tolerance against the presence of functional groups. This characteristic allows the use of coupling reactions in the synthesis of very complex molecules and thus, coupling reactions are widely used in the chemical and pharmaceutical industry, e.g. for the preparation of agricultural chemicals, pharmaceuticals, and dyestuffs, and, if vinyl compounds are coupled, to prepare monomers for polymerization reactions.

Suitable reactants for the coupling reactions are aryl, heteroaryl and vinyl halides, triflates, and other pseudohalides. The coupling reactions are catalyzed by transition metal compounds, typically palladium or nickel compounds. Palladium catalysts are generally advantageous in terms of the breadth of applicability of coupling substrates and in some cases the catalyst activity, while nickel catalysts have advantages in the area of the conversion of chloroaromatics and vinyl chlorides and the price of the metal. Palladium and nickel catalysts used to activate the aryl, heteroaryl and vinyl halides/pseudohalides are palladium(II) and/or nickel(II) as well as palladium(0) and/or nickel(0) complexes, although it is known that palladium(0)/nickel(0) compounds are the actual reaction catalysts. In particular, according to literature sources, coordinatively unsaturated 14-electron and 16-electron palladium(0)/nickel(0) complexes stabilized with donor ligands such as phosphines are formulated as active species.

Amongst the above-mentioned educts for coupling reactions, the iodides are the most reactive ones. It is even possible to use palladium or nickel compounds that are not stabilized by a phosphine or a similar donor ligand when iodides are employed as educts in coupling reactions. However, aryl and vinyl iodides are very expensive starting compounds and moreover produce stoichiometric amounts of iodine salt waste. The remaining educts, i.e. the aryl, heteroaryl and vinyl bromides, chlorides, triflates and other pseudohalides require the use of stabilizing and activating ligands in order to become effective in catalytic production.

Until some years ago, exclusively iodides, bromides, and triflates were used as educts in most of the catalyzed coupling reactions described. Obviously, organic chlorides were not employed as reactants although they should be the most appropriate reactants due to their low costs and great variety. Unfortunately, the chlorides proved to be generally not reactive under the reaction conditions used for coupling of iodides, bromides, and triflates. The low reactivity of chlorides is usually attributed to the strength of the C—Cl bond. Accordingly, the oxidative addition of the chlorides to the metal center of the catalyst (e.g. Pd⁰) occurs only reluctantly; however, this is the crucial first step in metal-catalyzed coupling reactions. Only within the last years, some progress was made concerning the development of new palladium-based catalysts that are effective in the coupling of chlorides.

The catalyst systems described for coupling reactions often have satisfactory catalytic turnover numbers (TONs) only with uneconomic starting materials such as iodides and activated bromides. Otherwise, in the case of deactivated bromides and especially in the case of chlorides, it is generally necessary to add large amounts of catalyst, usually more than 1 mol %, to achieve industrially useful yields (>90%). In addition, because of the complexity of the reaction mixtures, simple catalyst recycling is not possible, so the recycling of the catalyst also incurs high costs, which are normally an obstacle to realization on the industrial scale. Furthermore, particularly in the preparation of active substances or active substance precursors, it is undesirable to work with large amounts of catalyst because of the catalyst residues left behind in the product. More recent active catalyst systems are based on cyclopalladized phosphines (W. A. Herrmann, C. Brossmer, K. Öfele, C.-P. Reisinger, T. Priermeier, M. Beller, H. Fischer, Angew. Chem. 1995, 107, 1989; Angew. Chem. Int. Ed. Engl. 1995, 34, 1844) or mixtures of bulky arylphosphines (J. P. Wolfe, S. L. Buchwald, Angew. Chem. 1999, 111, 2570; Angew. Chem. Int. Ed. Engl. 1999, 38, 2413) or tri-tert.-butylphosphine (A. F. Littke, G. C. Fu, Angew. Chem. 1998, 110, 3586; Angew. Chem. Int. Ed. Engl. 1998, 37, 3387) with palladium salts or palladium complexes.

However, even with these catalysts, cost-effective chlorides cannot generally be activated satisfactorily from the industrial point of view. Therefore, to achieve high yields, it is necessary to use comparatively large and hence very expensive amounts of catalyst. Unfortunately, the current noble metal prices are still high, so there is clearly a need for improving catalyst productivity. Therefore, despite all the catalyst developments in recent years, only a few industrially applicable reactions have so far been disclosed for the coupling of chlorides.

The properties of transition metal catalyst complexes are recognized to be influenced by both the characteristics of the metal and those of the ligands associated with the metal atom. For example, structural features of the ligands can influence reaction rate, regioselectivity, and stereoselectivity.

Trialkylphosphines with bulky substituents are highly useful ligands for transition metal complexes, especially palladium complexes, as catalysts in various types of coupling reactions. The main reasons for the favorable catalytic properties of trialkylphosphine palladium complexes are the electron-richness and the steric bulk of trialkylphosphine ligands, which favor the formation of low coordinate and highly active Pd complexes also observed with N-heterocyclic carbenes as Pd ligands in cross-coupling reactions. Prominent examples of phosphines are PCy₃, P(tert.-Bu)₃ and ligands of the Ad₂PR type (Ad=1-adamantyl, R═CH₂Ph, n-Bu) (Beller et al., Angew. Chem. Int. Ed. 2000, 4153, and WO-A-02/10178). Especially PtBu₃ is highly useful; its utility for a wide range of different coupling reactions has been established.

A significant disadvantage of Pd catalysts based on bulky trialkylphosphines, primarily (tert.-Bu)₃P, is the lack of flexibility in the design of ligands and catalysts. Detailed structural and electronic modifications (“catalyst fine tuning”) are difficult to realize and this could be the reason why in cross-coupling chemistry this class of ligands was “leader of the pack” only about five years ago. Today numerous other specialized and more powerful catalysts, often based on phosphines and N-heterocyclic carbenes as ligands for Pd are available. Examples of phosphines having a highly variable ligand backbone are the Buchwald type biphenyl based phosphines (S. Buchwald et al., J. Am. Chem. Soc. 1998, 9722, EP-A-1 097 158) and N-phenyl-2-pyrrole based phosphines (M. Beller et al., Chem. Comm. 2004, 38). These types of ligands exhibit a good performance in numerous coupling reactions because they allow a fine tuning of their steric and electronic properties.

One object of the present invention is to provide new phosphines preferably exhibiting crucial properties for good ligands such as electron-richness and efficient-donation as perfectly met in trialkylphosphines, but lacking the disadvantages of the trialkylphosphines, i.e. they should have a variable ligand backbone. The new phosphines should be useful as ligands in new catalyst systems that possess greater substrate flexibility, e.g., the ability to utilize cost-effective organic chlorides as educts, and are suitable for a great variety of industrial scale reactions, preferably coupling reactions, that produce the desired products in high yield, with high catalytic productivity, and/or with high purity.

The object is achieved by a phosphine compound represented by the general formula (1)

or a corresponding phosphonium salt represented by the general formula (1a)

wherein R′ and R″ independently are selected from alkyl, cycloalkyl and 2-furyl radicals, or R′ and R″ are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon-phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; Cp^(s) is a partially substituted or completely substituted cyclopentadien-1-yl group, including substitutions resulting in a fused ring system, and wherein a substitution at the 1-position of the cyclopentadien-1-yl group is mandatory when the cyclopentadien-1-yl group is not part of a fused ring system or is part of an indenyl group; and Y⁻ represents an anion; excluding a phosphine compound represented by formula (A)

and their corresponding phosphonium salts (Aa) and (Ba), wherein Me represents a methyl radical and tBu represents a t-butyl radical.

The present invention is also directed to a coordination compound comprising (i) a phosphine compound represented by the general formula (1) wherein R′, R″, and Cp^(s) are defined as above, and (ii) a transition metal selected from groups 8, 9, 10 and 11 of the Periodic Table of the Elements. A further aspect of the present invention is the use of said coordination compound as a catalyst or a part of a catalyst system for the preparation of an organic compound.

Yet another aspect of the present invention is the use of a phosphine compound represented by the general formula (1) or a corresponding phosphonium salt represented by the general formula (1a) wherein R′, R″, Cp^(s) and Y⁻ are defined as above, in combination with a transition metal compound as a catalyst or a part of a catalyst system for the preparation of an organic compound wherein the transition metal is selected from groups 8, 9, 10, and 11 of the Periodic Table of the Elements.

The present invention is further directed to process for the preparation of said phosphine compound comprising the steps of: deprotonating a compound according to the formula HCp^(s) by the use of a strong base and reacting the resulting anion with a phosphinous halide according to the formula R′R″PX to form the phosphine compound R′R″PCp^(s), wherein Cp^(s), R′ and R″ are defined as above and X is Cl or Br. The present invention is also directed to an alternative process for the preparation of said phosphine compound comprising the steps of: deprotonating a compound according to the formula HCp^(s) by the use of a strong base and reacting the resulting anion with a phosphonous dihalide according to the formula R′PX₂ to form the phosphinous halide according to the formula Cp^(s)R'PX, and alkylating the phosphinous halide with an appropriate organometallic alkylation agent to introduce the R″ group and to form the phosphine compound R′R″PCp^(s), wherein Cp^(s), R′ and R″ are defined as above and X is Cl or Br.

Within the present application the following abbreviations are used to represent a specific radical:

Me=methyl; Et=ethyl; iPr=isopropyl; nPr=n-propyl; tBu=tert.-butyl; nBu=n-butyl; Cy=cyclohexyl; Neo-Pn=neopentyl; Ad=adamantly; Bn=benzyl; Ph=phenyl, and Cp=cyclopentadien-1-yl.

The Cp^(s) group is a monocycle (i.e. a cyclopentadienyl group) or a multicycle (e.g. an indenyl group when one benzene ring is fused to the cyclopentadienyl group or a fluorenyl group when two benzene rings are fused to the cyclopentadienyl group).

Phosphine compounds comprising an unsubstituted cyclopentadienyl group or an unsubstituted indenyl group as one substituent as well as transition metal complexes comprising those phosphines as ligands are known from the literature (Kolodyazhnyi, O. I., “Reaction of phosphorylated phosphorus(III) carbon acids with carbon tetrahalides” in Zhurnal Obshchei Khimii (1980), 50(8), 1885-6; Kolodyazhnyi, O. I., “Reaction of sterically hindered phosphines with carbon tetrahalides” in Zhurnal Obshchei Khimii (1981), 51(11), 2466-80; and Fallis, Kathleen A.; Anderson, Gordon K.; Rath, Nigam P., “Synthesis of two isomers of (diphenylphosphino)indene and their platinum(II) complexes” in Organometallics (1992), 11(2), 885-8). However, the use of these transition metal complexes in catalytic reactions has not been described. Only, metallocene type coordination compounds, e.g. a ferrocene type coordination compound, wherein one or two cyclopentadienyl dialkyl or diarylphosphine ligands are bound to the metal atom, e.g. Fe, via their delocalized π-electrons in an η⁵-bonding mode and their use as part of a catalyst system are disclosed in the prior art (Dubbaka, Srinivas Reddy; Vogel, Pierre, “Palladium-Catalyzed Suzuki-Miyaura Cross-Couplings of Sulfonyl Chlorides and Boronic Acids” in Organic Letters (2004), 6(1), 95-98; Kawatsura, Motoi; Hartwig, John F., “Simple, Highly Active Palladium Catalysts for Ketone and Malonate Arylation Dissecting the Importance of Chelation and Steric Hindrance” in Journal of the American Chemical Society (1999), 121(7), 1473-1478; Hamann, Blake C.; Hartwig, John F., “Sterically Hindered Chelating Alkyl Phosphines Provide Large Rate Accelerations in Palladium-Catalyzed Amination of Aryl Iodides, Bromides, and Chlorides, and the First Amination of Aryl Tosylates” in Journal of the American Chemical Society (1998), 120(29), 7369-7370). In those metallocene type compounds the cyclopentadienyl dialkyl or diaryl phosphine ligands formally are aromatic anions; hence, the electronic structure of those compounds is completely different to that in a coordination compound according to the present invention.

A phosphine compound according to formula (A) above comprising a pentamethylcyclopentadienyl group as one substituent is also known from the prior art (Jutzi, Peter; Saleske, Hartmut; Nadler, Doris, “The synthesis of thermally stable pentamethylcyclopentadienyl-substituted phosphorus compounds” in Journal of Organometallic Chemistry (1976), 118(1), C8-C10; and Jutzi, Peter; Saleske, Hartmut, “Synthesis and dynamic behavior of pentamethylcyclopentadienylphosphines” in Chemische Berichte (1984), 117(1), 222-33). However, neither its use as phosphine ligand in transition metal complexes nor its use in catalytic reactions has been mentioned.

Another group of known compounds comprising a pentamethylcyclopentadienyl-substituted phosphorous atom are P-pentamethylcyclopentadienyl-substituted 1H-phosphirenes that are employed as ligands in tungsten complexes (Streubel, Rainer; Bodea, Maren; Schiemann, Udo; Wismach, Cathleen; Jones, Peter G.; Monsees, Axel, “Synthesis of the first pentacarbonyltungsten(0) complexes with P-pentamethylcyclopentadienyl-substituted 1H-phosphirene ligands: Crystal structure of [cyclic][{Me₅C₅PCH:CPh}W(CO)₅]”, Zeitschrift für Anorganische and Allgemeine Chemie (2004), 630(8-9), 1215-1219). However, the use of these tungsten complexes in catalytic reactions has not been disclosed.

Only few phosphine compounds comprising a fluorenyl group as one substituent have been described in the literature. The publication by L. Baiget et al. in Phosphorous Sulfur 2003, 178, 1949 only refers to fluorenyl diarylphosphines. O. I. Kolodyazhnyi, J. Gen. Chem. USSR 1981, 51, 2125 discloses fluorenyl di-t.-butylphosphine according to formula (B), its preparation and its conversion to a P-ylid. Again, these references are silent about the use of these phosphine compounds as phosphine ligands in transition metal complexes or their use in catalytic reactions.

It was in fact surprising and it was the merit of the present inventors to have found out that the phosphine compounds according to the present invention can be used as ligands in transition metal complexes that may function as highly efficient catalysts.

R′ and R″ may independently be selected from alkyl, preferably C₁ to C₁₈ alkyl, more preferably C₁ to C₅ alkyl, most preferably C₃ to C₅ alkyl; cycloalkyl, preferably C₅ to C₁₂ cycloalkyl, more preferably C₅ to C₁₀ cycloalkyl, most preferably C₆ to C₈ cycloalkyl; and 2-furyl. The alkyl radicals may be branched or unbranched. Preferred alkyl radicals are selected from isopropyl, n-butyl, t-butyl, and neopentyl. Most preferred is isopropyl. The cycloalkyl radicals may be monocyclic or multicyclic, such as adamantyl and norbornyl. Preferred cycloalkyl radicals are cyclohexyl and adamantly. Preferably, R′ and R″ represent the same radicals, more preferably both are isopropyl or cyclohexyl. All the foregoing radicals represented by R′ and R″ are unsubstituted or may be substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals. Preferably, the radicals represented by R′ and R″ are unsubstituted.

In an alternative embodiment R′ and R″ are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon-phosphorous bicycle. The carbon-phosphorous monocycle is typically unsubstituted, but may also be substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals. Preferably, R′ and R″ are joined together to form a [3.3.1]- or [4.2.1]-phobyl radical with the phosphorous atom as depicted below.

In the first class of phosphine compounds according to the present invention Cp^(s) in formulae (1) and (1a) is a monocycle, i.e. a partially substituted or completely substituted cyclopentadien-1-yl group. Preferably, the phosphine compound and its corresponding phosphonium salt according to this embodiment are represented by formulae (2) and (2a):

wherein R is selected from the group consisting of aliphatic, heteroaliphatic, aromatic, alicyclic, heterocyclic radicals, heteroatom-containing radicals comprising an aromatic, alicyclic, or heterocyclic radical and an additional heteroatom linking the aromatic, alicyclic, or heterocyclic radical atom with the carbon atom of the cyclopentadienyl group, all the foregoing radicals being unsubstituted or substituted by further carbon and/or heteroatoms; and organosilyl radicals; R¹, R², R³, and R⁴ independently are selected from the group consisting of hydrogen; aliphatic, heteroaliphatic, aromatic, alicyclic, heterocyclic radicals, heteroatom-containing radicals comprising an aromatic, alicyclic, or heterocyclic radical and an additional heteroatom linking the aromatic, alicyclic, or heterocyclic radical atom with the carbon atom of the cyclopentadienyl group, all the foregoing radicals being unsubstituted or substituted by further carbon and/or heteroatoms; halogens; and heteroatom-containing groups.

Within the context of the present invention, aliphatic radicals include alkyl, alkenyl, and alkynyl radicals; the radicals may be branched or unbranched. Heteroaliphatic radicals include alkyl, alkenyl, and alkynyl radicals additionally comprising at least one heteroatom, e.g. oxygen or sulfur, within their backbone or as linking atom; the radicals may be branched or unbranched. Alicyclic radicals include cycloalkyl, cycloalkenyl, and cycloalkynyl radicals; the term “alicyclic” also encompasses multicyclic systems. Aromatic radicals include monocyclic and multicyclic systems. Heterocyclic radicals include alicyclic radicals containing at least one heteroatom within the ring structure and aromatic radicals containing at least one heteroatom within the ring structure. “Unsubstituted” means substituted by only hydrogen atoms. “Substituted by further carbon atoms” means that at least one further carbon atom is bonded to the radical. Said carbon atom may be part of a hydrocarbyl group, e.g. aliphatic radicals may be substituted by aromatic radicals forming aralkyl radicals, and vice versa aromatic radicals may be substituted by aliphatic radicals forming alkylaryl radicals. Said carbon atom may also be part of a group comprising heteroatom(s), e.g. —CN, a carboxylic acid group, including the salt forms, or a carboxylic acid ester group. “Substituted by heteroatoms” means that at least one heteroatom is bonded to the radical. The heteroatom may be a single atom, such as a halogen atom, or may be bonded to further atoms thus forming a small group (e.g. —OH) or larger group (e.g. —NO₂). A “heteroatom-containing group” is any group that comprises at least one heteroatom, including groups that impart functionality and/or water-solubility to the molecule. Examples of heteroatom-containing groups are —SO₃H, —OSO₂Ph, —CN, —OP(O)Ph₂, —NO₂, organosilyl, e.g. —SiMe₃ and SiPhMe₂.

With respect to formulae (2) and (2a) R is preferably selected from the group consisting of alkyl, cycloalkyl, aryl, aralkyl, alkenyl, alkynyl, alkoxy, and alkylsilyl radicals that are unsubstituted or substituted by further carbon and/or heteroatoms. More preferably, R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-octadecyl, benzyl, and phenyl radicals that are unsubstituted or substituted, preferably unsubstituted. Even more preferably, R is an unbranched alkyl radical or a benzyl radical. Most preferably R is a methyl or ethyl radical with methyl being even more preferred.

With respect to formulae (2) and (2a) R¹, R², R³, and R⁴ are preferably independently selected from the group consisting of hydrogen; alkyl, cycloalkyl, aryl, and alkoxy radicals that are unsubstituted or substituted; halogens; and heteroatom-containing groups. More preferably, R¹, R², R³, and R⁴ are independently selected from the group consisting of hydrogen, a methyl radical, a methoxy radical, and —SO—H. Even more preferably, R¹, R², R³, and R⁴ are independently selected from hydrogen and methyl radicals. Most preferably R¹, R², R³, and R⁴ are each a methyl radical.

Specific examples of cyclopentadienyl-substituted phosphine compounds according to formulae (2) and (2a) are compounds wherein the radicals R, R′, R″, R¹, R², R³, and R⁴ are defined as in the following table:

No. R R′ R″ R¹ R² R³ R⁴ 14/14a Me Cy Cy Me Me Me Me 15/15a Me iPr iPr Me Me Me Me Me tBu tBu Me Me Me Me Me Ad Ad Me Me Me Me Ph Cy Cy Ph Ph Ph Ph Ph iPr iPr Ph Ph Ph Ph Ph tBu tBu Ph Ph Ph Ph Ph Ad Ad Ph Ph Ph Ph Me Neo-Pn Neo-Pn Me Me Me Me Me Cy nBu Me Me Me Me Me tBu nBu Me Me Me Me

For the ease of preparation, the most preferred cyclopentadienyl-substituted phosphine compounds according to formulae (2) and (2a) are those wherein R, R′, R², R³, and R⁴ are each a methyl radical. Examples of these pentamethylcycopentadienyl-substituted phosphine compounds are:

-   (1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl)dicyclhexylphosphine     (Cp*PCy₂) (14),

-   (1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl)dicyclhexylphosphine     (Cp*PiPr₂) (15),

and their corresponding phosphonium salts Cp*PCy₂.H⁺Y⁻ (14a) and Cp*PiPr₂.H⁺Y⁻ (15a), wherein Cp* represents a 1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl radical.

In the second class of phosphine compounds according to the present invention Cp^(s) in formulae (1) and (1a) is a bicycle, i.e. a partially substituted or completely substituted ind-2-en-1-yl or ind-2-en-2-yl group, preferably a partially substituted or completely substituted ind-2-en-1-yl group. More preferably, the phosphine compound and its corresponding phosphonium salt according to this embodiment are represented by formulae (3) and (3a):

wherein R is selected from the group consisting of aliphatic, heteroaliphatic, aromatic, alicyclic, heterocyclic radicals, and aromatic, alicyclic, and heteroatom-containing radicals comprising an aromatic, alicyclic, or heterocyclic radical and an additional heteroatom linking the aromatic, alicyclic, or heterocyclic radical atom with the carbon atom of the indenyl group, all the foregoing radicals being unsubstituted or substituted by further carbon or heteroatoms; and organosilyl radicals; R⁵, R⁶, R⁷, R⁸, R⁹, and R¹⁰ independently are selected from the group consisting of hydrogen; aliphatic, heteroaliphatic, aromatic, alicyclic, heterocyclic radicals, heteroatom-containing radicals comprising an aromatic, alicyclic, or heterocyclic radical and an additional heteroatom linking the aromatic, alicyclic, or heterocyclic radical atom with the carbon atom of the indenyl group, all the foregoing radicals being unsubstituted or substituted by further carbon and/or heteroatoms; halogens; and heteroatom-containing groups.

With respect to formulae (3) and (3a) R is preferably selected from the group consisting of alkyl, cycloalkyl, aryl, aralkyl, alkenyl, alkynyl, alkoxy, and alkylsilyl radicals that are unsubstituted or substituted by further carbon and/or heteroatoms. More preferably, R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-octadecyl, benzyl, and phenyl radicals that are unsubstituted or substituted, preferably unsubstituted. Even more preferably, R is an unbranched alkyl radical or a benzyl radical. Most preferably R is a methyl or ethyl radical with methyl being even more preferred.

With respect to formulae (3) and (3a) R⁵, R⁶, R⁷, R⁸, R⁹, and R¹⁰ are preferably independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, and alkoxy radicals that are unsubstituted or substituted; halogens, and heteroatom-containing groups. More preferably, R⁵, R⁶, R⁷, R⁸, R⁹, and R¹⁰ are independently selected from the group consisting of hydrogen, a methyl radical, a methoxy radical, and —SO₃H. Most preferably, R⁵, R⁶, R⁷, R⁸, R⁹, and R¹⁰ are independently selected from the group consisting of hydrogen, a methyl radical, and a methoxy radical.

Specific examples of indenyl-substituted phosphine compounds according to formulae (3) and (3a) are compounds wherein the radicals R, R′, R″, R⁵, R⁶, R⁷, R⁸, R⁹, and R¹⁰ are defined as in the following table:

No. R R′ R″ R⁵ R⁶ R⁷ R⁸ R⁹ R¹⁰ 17/17a Me iPr iPr Me Me H H H H Me iPr iPr Me Me Me Me Me Me 19/19a Me iPr iPr Me Me Me H H Me 21/21a Me iPr iPr Me Me OMe H H OMe Me iPr iPr Me Me Me SO₃H H Me Me iPr iPr Me Me iPr H H iPr 16/16a Me Cy Cy Me Me H H H H Me Cy Cy Me Me Me Me Me Me 18/18a Me Cy Cy Me Me Me H H Me 20/20a Me Cy Cy Me Me OMe H H OMe Me Cy Cy Me Me Me SO₃H H Me Me Cy Cy Me Me iPr H H iPr Me tBu nBu Me Me H H H H Me tBu nBu Me Me Me Me Me Me Me tBu nBu Me Me Me H H Me Me tBu nBu Me Me OMe H H OMe Me tBu nBu Me Me Me SO₃H H Me Me tBu nBu Me Me i-Pr H H iPr Bn iPr iPr Me Me H H H H Bn iPr iPr Me Me Me Me Me Me Bn iPr iPr Me Me Me H H Me Bn iPr iPr Me Me OMe H H OMe Bn iPr iPr Me Me Me SO₃H H Me Bn iPr iPr Me Me iPr H H iPr Bn Cy Cy Me Me H H H H Bn Cy Cy Me Me Me Me Me Me Bn Cy Cy Me Me Me H H Me Bn Cy Cy Me Me OMe H H OMe Bn Cy Cy Me Me Me SO₃H H Me Bn Cy Cy Me Me iPr H H iPr Bn tBu nBu Me Me H H H H Bn tBu nBu Me Me Me Me Me Me Bn tBu nBu Me Me Me H H Me Bn tBu nBu Me Me OMe H H OMe Bn tBu nBu Me Me Me SO₃H H Me Bn tBu nBu Me Me iPr H H iPr

In a preferred embodiment R, R⁵ and R⁶ in formulae (3) or (3a) are each a methyl radical, more preferably R⁷, R⁸, R⁹ and R¹⁰ are independently selected from the group consisting of hydrogen, a methyl radical and a methoxy radical. In this embodiment it is advantageous that R⁷, R⁸, R⁹ and R¹⁰ are either each hydrogen or R⁸ and R⁹ are each hydrogen and R⁷ and R¹⁰ are non-hydrogen radicals. Examples of this embodiment of indenyl-substituted phosphine compounds are:

-   (1,2,3-trimethylind-2-en-1-yl)dicyclohexylphosphine     (1,2,3-Me₃IndPCy₂) (16),

-   (1,2,3-trimethylind-2-en-1-yl)diisopropylphosphine     (1,2,3-Me₃IndPiPr₂) (17),

-   (1,2,3,4,7-pentamethylind-2-en-1-yl)dicyclohexylphosphine     (1,2,3,4,7-Me₅IndPCy₂) (18),

-   (1,2,3,4,7-pentamethylind-2-en-1-yl)diisopropylphosphine     (1,2,3,4,7-Me₅IndPiPr₂) (19),

-   (4,7-dimethoxy-1,2,3-trimethylind-2-en-1-yl)dicyclohexylphosphine     (4,7-(MeO)₂-1,2,3-Me₃IndPCy₂) (20),

-   (4,7-dimethoxy-1,2,3-trimethylind-2-en-1-yl)diisopropylphosphine     (4,7-(MeO)₂-1,2,3-Me₃IndPiPr₂) (21),

and their corresponding phosphonium salts

-   1,2,3-Me₃IndPCy₂.H⁺Y⁻ (16a), -   1,2,3-Me₃IndPiPr₂.H⁺Y⁻ (17a), -   1,2,3,4,7-Me₅IndPCy₂.H⁺Y⁻ (18a), -   1,2,3,4,7-Me₅IndPiPr₂.H⁺Y⁻ (19a), -   4,7-(MeO)₂-1,2,3-Me₃IndPCy₂.H⁺Y⁻ (20a), and -   4,7-(MeO)₂-1,2,3-Me₃IndPiPr₂.H⁺Y⁻ (21a),     wherein Ind represents an ind-2-en-1-yl radical and Cy, iPr, and Me     have the meanings defined above.

In the third class of phosphine compounds according to the present invention Cp^(s) in formulae (1) and (1a) is a tricycle, i.e. an unsubstituted, partially substituted or completely substituted fluoren-9-yl group, including substitutions resulting in an enlarged fused ring system. Preferably, the phosphine compound and its corresponding phosphonium salt according to this embodiment are represented by formulae (4) and (4a):

wherein R is selected from the group consisting of hydrogen; aliphatic, heteroaliphatic, aromatic, alicyclic, heterocyclic radicals, and heteroatom-containing radicals comprising an aromatic, alicyclic, or heterocyclic radical and an additional heteroatom linking the aromatic, alicyclic, or heterocyclic radical atom with the carbon atom of the fluorenyl group, all the foregoing radicals being unsubstituted or substituted by further carbon and/or heteroatoms; and organosilyl radicals; R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ independently are selected from the group consisting of hydrogen; aliphatic, heteroaliphatic, aromatic, alicyclic, heterocyclic radicals, heteroatom-containing radicals comprising an aromatic, alicyclic, or heterocyclic radical and an additional heteroatom linking the aromatic, alicyclic, or heterocyclic radical atom with the carbon atom of the fluorenyl group, all the foregoing radicals being unsubstituted or substituted by further carbon and/or heteroatoms; halogens, and heteroatom-containing groups.

With respect to formulae (4) and (4a) R is preferably selected from the group consisting of alkyl, cycloalkyl, aryl, aralkyl, alkenyl, alkynyl, alkoxy, and alkylsilyl radicals that are unsubstituted or substituted by further carbon and/or heteroatoms. More preferably, R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-octadecyl, benzyl, and phenyl radicals that are unsubstituted or substituted, preferably unsubstituted. Even more preferably, R is an unbranched alkyl radical or a benzyl radical. Most preferably R is a methyl or ethyl radical with ethyl being even more preferred.

With respect to formulae (4) and (4a) R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ are preferably independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, and alkoxy radicals that are unsubstituted or substituted; halogens, and heteroatom-containing groups. More preferably, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ are independently selected from the group consisting of hydrogen, a methyl radical, a methoxy radical, and —SO₃H. Even more preferably, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ are independently selected from the group consisting of hydrogen, a methyl radical, and a methoxy radical. Still more preferably, R¹⁴ and R¹⁵ are each hydrogen and R¹¹, R¹², R¹³, R¹⁶, R¹⁷, and R¹⁸ are independently selected from hydrogen and methyl radicals. Still more preferably R¹³, R¹⁴, R¹⁵, and R¹⁶ are each hydrogen. Most preferably and R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸ are each hydrogen.

In another embodiment of the present invention R¹² and/or R¹⁷ in formulae (4) or (4a) are a halogen or a heteroatom-containing group, preferably both are Br or one of them is —SO₃H, the remaining radicals of R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ are each hydrogen.

Specific examples of fluorenyl-substituted phosphine compounds according to formulae (4) and (4a) are compounds wherein the radicals R, R′, R″, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ are defined as in the following table:

No. R R′ R″ R¹¹ R¹² R¹³ R¹⁴ R¹⁵ R¹⁶ R¹⁷ R¹⁸ 8/8a Me Cy Cy H H H H H H H H 5/5a Me iPr iPr H H H H H H H H 9/9a Et Cy Cy H H H H H H H H 6/6a Et iPr iPr H H H H H H H H 22/22a iPr Cy Cy H H H H H H H H 23/23a iPr iPr iPr H H H H H H H H 24/24a nPr Cy Cy H H H H H H H H 25/25a H tBu tBu H H H H H H H H 11/11a C₁₈H₃₇ Cy Cy H H H H H H H H 7/7a C₁₈H₃₇ iPr iPr H H H H H H H H 10/10a Bn Cy Cy H H H H H H H H 26/26a Bn iPr iPr H H H H H H H H 27/27a Bn tBu nBu H H H H H H H H 28/28a Et tBu nBu H H H H H H H H 12/12a Et Cy Cy Me H H H H H H H 29/29a Et Cy Cy Me H Me H H H H Me 30/30a Ph iPr iPr H H H H H H H H 13/13a Et Cy Cy H SO₃H H H H H H H 31/31a Et iPr iPr H Br H H H H Br H Me iPr iPr Me H H H H H H Me Me iPr iPr iPr H H H H H H iPr Me iPr iPr OMe H H H H H H OMe Me iPr iPr H Br H H H H Br H Me iPr iPr Me Br H H H H Br Me Me iPr iPr iPr Br H H H H Br iPr Me iPr iPr OMe Br H H H H Br OMe Me iPr iPr H SO₃H H H H H H H Me iPr iPr Me SO₃H H H H H H Me Me iPr iPr iPr SO₃H H H H H H iPr Me iPr iPr OMe SO₃H H H H H H OMe Me iPr iPr H SO₃H H H H H SO₃H H Me iPr iPr Me SO₃H H H H H SO₃H Me Me iPr iPr iPr SO₃H H H H H SO₃H iPr Me iPr iPr OMe SO₃H H H H H SO₃H OMe Me iPr iPr Me H H H H H H H Me iPr iPr iPr H H H H H H H Me iPr iPr OMe H H H H H H H Me iPr iPr Me H H H H Me H Me Me Cy Cy Me H H H H H H Me Me Cy Cy iPr H H H H H H iPr Me Cy Cy OMe H H H H H H OMe Me Cy Cy H Br H H H H Br H Me Cy Cy Me Br H H H H Br Me Me Cy Cy iPr Br H H H H Br iPr Me Cy Cy OMe Br H H H H Br OMe Me Cy Cy H SO₃H H H H H H H Me Cy Cy Me SO₃H H H H H H Me Me Cy Cy iPr SO₃H H H H H H iPr Me Cy Cy OMe SO₃H H H H H H OMe Me Cy Cy H SO₃H H H H H SO₃H H Me Cy Cy Me SO₃H H H H H SO₃H Me Me Cy Cy iPr SO₃H H H H H SO₃H iPr Me Cy Cy OMe SO₃H H H H H SO₃H OMe Me Cy Cy Me H H H H H H H Me Cy Cy iPr H H H H H H H Me Cy Cy OMe H H H H H H H Me Cy Cy Me H H H H Me H Me Me tBu nBu H H H H H H H H Me tBu nBu Me H H H H H H Me Me tBu nBu iPr H H H H H H iPr Me tBu nBu OMe H H H H H H OMe Me tBu nBu H Br H H H H Br H Me tBu nBu Me Br H H H H Br Me Me tBu nBu iPr Br H H H H Br iPr Me tBu nBu OMe Br H H H H Br OMe Me tBu nBu H SO₃H H H H H H H Me tBu nBu Me SO₃H H H H H H Me Me tBu nBu iPr SO₃H H H H H H iPr Me tBu nBu OMe SO₃H H H H H H OMe Me tBu nBu H SO₃H H H H H SO₃H H Me tBu nBu Me SO₃H H H H H SO₃H Me Me tBu nBu iPr SO₃H H H H H SO₃H iPr Me tBu nBu OMe SO₃H H H H H SO₃H OMe Me tBu nBu Me H H H H H H H Me tBu nBu iPr H H H H H H H Me tBu nBu OMe H H H H H H H Me tBu nBu Me H H H H Me H Me Et iPr iPr Me H H H H H H Me Et iPr iPr iPr H H H H H H iPr Et iPr iPr OMe H H H H H H OMe Et iPr iPr Me Br H H H H Br Me Et iPr iPr iPr Br H H H H Br iPr Et iPr iPr OMe Br H H H H Br OMe Et iPr iPr H SO₃H H H H H H H Et iPr iPr Me SO₃H H H H H H Me Et iPr iPr iPr SO₃H H H H H H iPr Et iPr iPr OMe SO₃H H H H H H OMe Et iPr iPr H SO₃H H H H H SO₃H H Et iPr iPr Me SO₃H H H H H SO₃H Me Et iPr iPr iPr SO₃H H H H H SO₃H iPr Et iPr iPr OMe SO₃H H H H H SO₃H OMe Et iPr iPr Me H H H H H H H Et iPr iPr iPr H H H H H H H Et iPr iPr OMe H H H H H H H Et iPr iPr Me H H H H Me H Me Et Cy Cy Me H H H H H H Me Et Cy Cy iPr H H H H H H iPr Et Cy Cy OMe H H H H H H OMe Et Cy Cy H Br H H H H Br H Et Cy Cy Me Br H H H H Br Me Et Cy Cy iPr Br H H H H Br iPr Et Cy Cy OMe Br H H H H Br OMe Et Cy Cy Me SO₃H H H H H H Me Et Cy Cy iPr SO₃H H H H H H iPr Et Cy Cy OMe SO₃H H H H H H OMe Et Cy Cy H SO₃H H H H H SO₃H H Et Cy Cy Me SO₃H H H H H SO₃H Me Et Cy Cy iPr SO₃H H H H H SO₃H iPr Et Cy Cy OMe SO₃H H H H H SO₃H OMe Et Cy Cy iPr H H H H H H H Et Cy Cy OMe H H H H H H H Et Cy Cy Me H H H H Me H Me Et tBu nBu Me H H H H H H Me Et tBu nBu iPr H H H H H H iPr Et tBu nBu OMe H H H H H H OMe Et tBu nBu H Br H H H H Br H Et tBu nBu Me Br H H H H Br Me Et tBu nBu iPr Br H H H H Br iPr Et tBu nBu OMe Br H H H H Br OMe Et tBu nBu H SO₃H H H H H H H Et tBu nBu Me SO₃H H H H H H Me Et tBu nBu iPr SO₃H H H H H H iPr Et tBu nBu OMe SO₃H H H H H H OMe Et tBu nBu H SO₃H H H H H SO₃H H Et tBu nBu Me SO₃H H H H H SO₃H Me Et tBu nBu iPr SO₃H H H H H SO₃H iPr Et tBu nBu OMe SO₃H H H H H SO₃H OMe Et tBu nBu Me H H H H H H H Et tBu nBu iPr H H H H H H H Et tBu nBu OMe H H H H H H H Et tBu nBu Me H H H H Me H Me Bn iPr iPr Me H H H H H H Me Bn iPr iPr iPr H H H H H H iPr Bn iPr iPr OMe H H H H H H OMe Bn iPr iPr H Br H H H H Br H Bn iPr iPr Me Br H H H H Br Me Bn iPr iPr iPr Br H H H H Br iPr Bn iPr iPr OMe Br H H H H Br OMe Bn iPr iPr H SO₃H H H H H H H Bn iPr iPr Me SO₃H H H H H H Me Bn iPr iPr iPr SO₃H H H H H H iPr Bn iPr iPr OMe SO₃H H H H H H OMe Bn iPr iPr H SO₃H H H H H SO₃H H Bn iPr iPr Me SO₃H H H H H SO₃H Me Bn iPr iPr iPr SO₃H H H H H SO₃H iPr Bn iPr iPr OMe SO₃H H H H H SO₃H OMe Bn iPr iPr Me H H H H H H H Bn iPr iPr iPr H H H H H H H Bn iPr iPr OMe H H H H H H H Bn iPr iPr Me H H H H Me H Me Bn Cy Cy Me H H H H H H Me Bn Cy Cy iPr H H H H H H iPr Bn Cy Cy OMe H H H H H H OMe Bn Cy Cy H Br H H H H Br H Bn Cy Cy Me Br H H H H Br Me Bn Cy Cy iPr Br H H H H Br iPr Bn Cy Cy OMe Br H H H H Br OMe Bn Cy Cy H SO₃H H H H H H H Bn Cy Cy Me SO₃H H H H H H Me Bn Cy Cy iPr SO₃H H H H H H iPr Bn Cy Cy OMe SO₃H H H H H H OMe Bn Cy Cy H SO₃H H H H H SO₃H H Bn Cy Cy Me SO₃H H H H H SO₃H Me Bn Cy Cy iPr SO₃H H H H H SO₃H iPr Bn Cy Cy OMe SO₃H H H H H SO₃H OMe Bn Cy Cy Me H H H H H H H Bn Cy Cy iPr H H H H H H H Bn Cy Cy OMe H H H H H H H Bn Cy Cy Me H H H H Me H Me Bn tBu nBu Me H H H H H H Me Bn tBu nBu iPr H H H H H H iPr Bn tBu nBu OMe H H H H H H OMe Bn tBu nBu H Br H H H H Br H Bn tBu nBu Me Br H H H H Br Me Bn tBu nBu iPr Br H H H H Br iPr Bn tBu nBu OMe Br H H H H Br OMe Bn tBu nBu H SO₃H H H H H H H Bn tBu nBu Me SO₃H H H H H H Me Bn tBu nBu iPr SO₃H H H H H H iPr Bn tBu nBu OMe SO₃H H H H H H OMe Bn tBu nBu H SO₃H H H H H SO₃H H Bn tBu nBu Me SO₃H H H H H SO₃H Me Bn tBu nBu iPr SO₃H H H H H SO₃H iPr Bn tBu nBu OMe SO₃H H H H H SO₃H OMe Bn tBu nBu Me H H H H H H H Bn tBu nBu iPr H H H H H H H Bn tBu nBu OMe H H H H H H H Bn tBu nBu Me H H H H Me H Me Ph iPr iPr Me H H H H H H Me Ph iPr iPr iPr H H H H H H iPr Ph iPr iPr OMe H H H H H H OMe Ph iPr iPr H Br H H H H Br H Ph iPr iPr Me Br H H H H Br Me Ph iPr iPr iPr Br H H H H Br iPr Ph iPr iPr OMe Br H H H H Br OMe Ph iPr iPr H SO₃H H H H H H H Ph iPr iPr Me SO₃H H H H H H Me Ph iPr iPr iPr SO₃H H H H H H iPr Ph iPr iPr OMe SO₃H H H H H H OMe Ph iPr iPr H SO₃H H H H H SO₃H H Ph iPr iPr Me SO₃H H H H H SO₃H Me Ph iPr iPr iPr SO₃H H H H H SO₃H iPr Ph iPr iPr OMe SO₃H H H H H SO₃H OMe Ph iPr iPr Me H H H H H H H Ph iPr iPr iPr H H H H H H H Ph iPr iPr OMe H H H H H H H Ph iPr iPr Me H H H H Me H Me Ph Cy Cy H H H H H H H H Ph Cy Cy Me H H H H H H Me Ph Cy Cy iPr H H H H H H iPr Ph Cy Cy OMe H H H H H H OMe Ph Cy Cy H Br H H H H Br H Ph Cy Cy Me Br H H H H Br Me Ph Cy Cy iPr Br H H H H Br iPr Ph Cy Cy OMe Br H H H H Br OMe Ph Cy Cy H SO₃H H H H H H H Ph Cy Cy Me SO₃H H H H H H Me Ph Cy Cy iPr SO₃H H H H H H iPr Ph Cy Cy OMe SO₃H H H H H H OMe Ph Cy Cy H SO₃H H H H H SO₃H H Ph Cy Cy Me SO₃H H H H H SO₃H Me Ph Cy Cy iPr SO₃H H H H H SO₃H iPr Ph Cy Cy OMe SO₃H H H H H SO₃H OMe Ph Cy Cy Me H H H H H H H Ph Cy Cy iPr H H H H H H H Ph Cy Cy OMe H H H H H H H Ph Cy Cy Me H H H H Me H Me Ph tBu nBu H H H H H H H H Ph tBu nBu Me H H H H H H Me Ph tBu nBu iPr H H H H H H iPr Ph tBu nBu OMe H H H H H H OMe Ph tBu nBu H Br H H H H Br H Ph tBu nBu Me Br H H H H Br Me Ph tBu nBu iPr Br H H H H Br iPr Ph tBu nBu OMe Br H H H H Br OMe Ph tBu nBu H SO₃H H H H H H H Ph tBu nBu Me SO₃H H H H H H Me Ph tBu nBu iPr SO₃H H H H H H iPr Ph tBu nBu OMe SO₃H H H H H H OMe Ph tBu nBu H SO₃H H H H H SO₃H H Ph tBu nBu Me SO₃H H H H H SO₃H Me Ph tBu nBu iPr SO₃H H H H H SO₃H iPr Ph tBu nBu OMe SO₃H H H H H SO₃H OMe Ph tBu nBu Me H H H H H H H Ph tBu nBu iPr H H H H H H H Ph tBu nBu OMe H H H H H H H Ph tBu nBu Me H H H H Me H Me

The bromine radicals (e.g. in phosphine compound no. 31) allow an easy introduction of additional functional groups.

Especially preferred are the following fluorenyl-substituted phosphine compounds:

-   (9-methylfluoren-9-yl)diisopropylphosphine (9-MeFluPiPr₂) (5),

-   (9-ethylfluoren-9-yl)diisopropylphosphine (9-EtFluPiPr₂) (6),

-   (9-benzylfluoren-9-yl)diisopropylphosphine (9-BnFluPiPr₂) (26),

-   (9-octadecylfluoren-9-yl)diisopropylphosphine C₁₈H₃₇FluPiPr₂) (7),

-   (9-methylfluoren-9-yl)dicyclohexylphosphine (9-MeFluPCy₂) (8),

-   (9-ethylfluoren-9-yl)dicyclohexylphosphine (9-EtFluPCy₂) (9),

-   (9-benzylfluoren-9-yl)dicyclohexylphosphine (9-BnFluPCy₂) (10),

-   (9-octadecylfluoren-9-yl)dicyclohexylphosphine (9-C₁₈H₃₇FluPCy₂)     (11)

-   (1-methyl-9-ethylfluoren-9-yl)dicyclohexylphosphine     (9-Et-1-MeFluPCy₂) (12),

-   (9-ethyl-2-sulfofluoren-9-yl)dicyclohexylphosphine     (2-SO₃H-9-EtFluPCy₂) (13),

and their corresponding phosphonium salts

-   9-MeFluPiPr₂.H′Y (5a), -   9-EtFluPiPr₂.H⁺Y⁻ (6a), -   9-BnFluPiPr₂.H⁺Y⁻ (26a), -   9-C₁₈H₃₇FluPiPr₂.H⁺Y⁻ (7a), -   9-MeFluPCy₂.H⁺Y⁻ (8a), -   9-EtFluPCy₂.H⁺Y⁻ (9a), -   9-BnFluPCy₂.H⁺Y⁻ (10a), -   9-C₁₈H₃₇FluPCy₂.H⁺Y⁻ (11a), -   9-Et-1-MeFluPCy₂.H⁺Y⁻ (12a), and -   9-Et-2-SO₃HFluPCy₂.H⁺Y⁻ (13a).     wherein Flu represents a fluoren-9-yl radical, and Et, Bn, Cy, iPr,     and Me have the meanings defined above.

In all the preceding formulae Y⁻ represents an anion, preferably a non-coordinating, non-basic anion such as BF₄ ⁻.

A general route for the preparation of the new phosphine compounds is as follows: A compound according to the formula HCp^(s) having the desired substitutions, typically a substituted cyclopentadiene, a substituted indene, or an unsubstituted or substituted fluorene, is first reacted with a strong base, typically n-BuLi, to abstract a proton and a resonance stabilized carbanion is formed. Next, the anion is reacted with a phosphinous halide according to the formula R′R″PX, wherein R′ and R″ are defined as above and X is Cl or Br, preferably Cl, to result in the respective Cp^(s)-substituted phosphine which is conveniently converted into the respective phosphonium salts for easier storage and handling (e.g. by reacting with HBF₄). This method is advantageously used to prepare phosphine compounds wherein R′ and R″ in formulae (1) or (1a) are the same radicals as the corresponding phosphinous halides are easily available.

Depending on the desired substituents at the Cp^(s) ring system it is required in some cases to prepare first a cyclopentadienyl-, indenyl- or fluorenyl-substituted phosphine compound and then perform the appropriate reactions to result in the desired substitutions at the Cp^(s) ring system. An example is the preparation of a sulfonated fluorenyl-substituted phosphine wherein a fluorenyl-substituted phosphonium salt is reacted with sulfuric acid to introduce an —SO₃ group at the fluorenyl radical.

Another modification of the general method becomes necessary when the R′ and R″ radicals are different and the corresponding phosphinous halide R′R″PX is not readily available. A compound according to the formula HCp^(s) having the desired substitutions, typically a substituted cyclopentadiene, a substituted indene, or an unsubstituted or substituted fluorene, is first reacted with a strong base, typically n-BuLi, to abstract a proton and a resonance stabilized carbanion is formed. Next, the anion is reacted with a phosphonous dihalide according to the formula R′PX₂ wherein R′ is defined as above and X is Cl or Br, preferably Cl, to result in the phosphinous halide according to the formula Cp^(s)R′PX as intermediate product. Cp^(s)R′PX can easily be converted to the desired phosphine R′R″PCp^(s) by simple alkylation with an appropriate organometallic reagent, such as R″MgX or R″Li wherein R″ is a defined above.

All three classes of new phosphine compounds are good ligands in metal complexes. The present inventors believe that e.g. the 9-fluorenyl group as well as the 1-indenyl group acts a an electron-rich alkyl substituent. Moreover, the close proximity of 6-systems seems to facilitate the stabilization of low coordinated metal species. However, the easy availability of the simpler cyclopentadienes, especially the pentamethylcyclopentadiene, makes phosphines prepared from these starting compounds also very attractive for economical reasons.

One aspect of the present invention is a coordination compound comprising a phosphine compound as described before (including phosphine compounds according to formulae (A) and (B)) and a transition metal selected from groups 8, 9, 10, and 11 of the Periodic Table of the Elements. Said coordination compounds are effective catalysts or effective parts of catalyst systems for organic synthesis. Said coordination compounds can either be prepared in advance and then used for catalytic reactions or can be formed in situ by adding the phosphine compound or its corresponding phosphonium salt in combination with an appropriate transition metal precursor compound. Thus, another aspect of the present invention is the use the phosphine compound (including phosphine compounds according to formulae (A) and (B)) or its corresponding phosphonium salt (including phosphonium salts according to formulae (Aa) and (Ba)) in combination with a transition metal compound as a catalyst or a part of a catalyst system for the preparation of an organic compound, wherein the transition metal is selected from groups 8, 9, 10, and 11 of the Periodic Table of the Elements. The in situ formation of the catalytically active coordination compound comprising the phosphine compound according to the invention as ligand is often more convenient; however it may also be advantageous to prepare the catalytically active coordination compound comprising the phosphine compound according to the invention as ligand directly and then use it for catalytic applications as this increases the initial catalytic activity in some instances. If it is referred to the “present catalyst” or “catalyst according to the invention” both alternative routes are included.

The transition metal is preferably selected from Pd, Ni, Pt, Rh, Ir, Ru, Co, Fe, Cu, and Au, more preferably it is Pd or Ni and most preferably it is Pd.

Examples of palladium compounds that can be used together with the phosphine compounds according to the invention in order to form in situ the catalytically active coordination compound comprising the phosphine compound as a ligand are palladium(II) acetate, palladium(II) chloride, palladium(II) bromide, sodium tetrachloropalladate (II), palladium (II) acetylacetonate, palladium(0) dibenzylidenacetone complexes, palladium(0) tetrakis(triphenylphosphine), palladium(0) bis(tri-o-tolylphosphine), palladium(II) propionate, palladium(II) (cyclooctadiene-1,5) dichloride, palladium(0)-diallyl ether complexes, palladium(II) nitrate, palladium(II) chloride bis(acetonitrile), palladium(II) chloride bis(benzonitrile) and other palladium(0) and palladium(II) complexes.

Generally, for catalytic applications, the phosphine ligand is used in excess relative to the transition metal. The ratio of transition metal to ligand is preferably from 1:1 to 1:1000. Ratios of transition metal to ligand of 1:1 to 1:100 are particularly preferred. The exact transition metal/ligand ratio to be used depends on the specific application and also on the amount of catalyst used. Thus, in general, it is conventional to use lower transition metal/ligand ratios in the case of very low transition metal concentrations (<0.01 mol %) than in the case of transition metal concentrations of between 0.5 and 0.01 mol % of transition metal.

The present phosphine compounds and their corresponding phosphonium salts are thermally very stable. It is thus possible to use the catalysts according to the invention at reaction temperatures of up to 250° C. or more. The catalysts are preferably used at temperatures of 20 to 200° C.; it has proved advantageous in many cases to work at temperatures of 30 to 180° C., preferably of 40 to 160° C. The ligands can also be used in pressure reactions without loss of activity, the operating pressure conventionally being up to only 100 bar, but preferably in the normal pressure range of up to 60 bar.

The present catalysts are preferably used in couplings reactions wherein a C—C or C-heteroatom bond is formed. However, it is obvious to those skilled in the art that other transition metal-catalyzed reactions, such as the metathesis or hydrogenation of double bonds or carbonyl compounds can also be catalyzed by the present catalysts.

An overview of Pd catalyzed coupling reactions illustrative for reactions that can be catalyzed by the catalysts according to the present invention, i.e. Pd complexes comprising the present phosphine compounds as ligands (prepared in advance or formed in situ), is disclosed in “Palladiumkatalysierte Kupplungen von Arylchloriden”, by A. F. Littke and G. C. Fu, Angew. Chem. 2002, 114, 4350-4386.

Examples of C—C coupling reactions are:

(a) Suzuki cross-coupling (also known as Suzuki-Miyaura cross-coupling) of organoboron compounds with aryl, heteroaryl or vinyl halides/pseudohalides: Typically, the organoboron compound is boronic acid of the formula R^(a)—B(OH)₂, wherein R^(a) is an aryl, alkenyl, or alkyl radical, or, although less preferred, a corresponding boronic acid ester. The reaction is conducted in the presence of the Pd complex and a base. The Suszuki cross-coupling is significant to couple aryl and heteroaryl boronic acid with aryl and heteroaryl halides, respectively, resulting in the formation of biaryl compounds. (b) Stille cross-coupling of organotin compounds with carbon electrophiles comprising a halogen or pseudohalogen as leaving group: Preferably, the carbon electrophile is an aryl, heteroaryl or vinyl halide/pseudohalide, although other electrophiles, such as acid halides, may be used. Typically, the organotin compound has the formula R^(b)Sn(R^(c))₃, wherein the R^(c) radicals being not transferred are usually butyl or methyl radicals and the R^(b) radical can be varied broadly, preferably it is an aryl, heteroaryl, alkenyl, alkynyl, or alkyl radical. The reaction is conducted in the presence of the Pd complex. Stille cross-coupling is a popular tool in the synthesis of complex natural products. (c) Hiyama cross-coupling of organosilanes with aryl, heteroaryl or vinyl halides/pseudohalides: Typically, the organosilane has the formula R^(d)SiZ, wherein Z represents three radicals that are not transferred, e.g. MeCl₂, Me_(a), and (OMe)₃, and R^(d) is, for example, a vinyl, akynyl, or aryl radical. The reaction is conducted in the presence of the Pd catalyst. The Hiyama cross-coupling is an interesting alternative to the Stille cross-coupling as organosilicon compounds are non-toxic. (d) Negishi cross-coupling of organozinc compounds with aryl, heteroaryl or vinyl halides/pseudohalides: Typically, the organozinc compound has the formula R^(e)ZnX or R^(e) ₂Zn, wherein X is a halogen or a phenyl radical and R^(e) is, for example, an aryl, heteroaryl, or alkyl radical. The reaction is conducted in the presence of the Pd catalyst. The Negishi cross-coupling is an effective method for the formation of C—C bonds as organozinc compounds are readily accessible and show a high tolerance against functional groups. (e) Kumada cross-coupling of Grignard compounds with aryl, heteroaryl or vinyl halides/pseudohalides: In the Grignard compound according to formula R^(f)MgX the R^(f) radical may be an aryl, heteroaryl, or alkyl radical and X is a halogen. The reaction is conducted in the presence of a Pd or Ni catalyst. The Kumada cross-coupling has reached a high significance in organic synthesis as it has been known for a long time. However, contrary to the coupling reactions mentioned above, its applicability is restricted as Grignard compounds do not tolerate a lot of functional compounds. (f) Sonogashira cross-coupling of terminal alkynes with aryl, heteroaryl or vinyl halides/pseudohalides: In the terminal alkyne according to formula H—C≡C—R^(f) the R^(f) radical can be varied broadly, even including organosilyl radicals. The reaction is conducted in the presence of the Pd catalyst and a Cu cocatalyst, typically CuI. (g) α-Arylation of enolates and other stabilized carbanions with aryl or heteroaryl halides/pseudohalides: The compounds to be arylated include carbonyl compounds, such as ketones and esters, and nitro compounds. The reaction is conducted in the presence of the Pd catalyst and a base. (h) Cyanation of aryl or heteroaryl halides/pseudohalides: Typically, the cyanation agent is an inorganic cyanide, such as Zn(CN)₂ or KCN. The reaction is conducted in the presence of the Pd catalyst. (i) Carbonylation of aryl or heteroaryl halides/pseudohalides: An aryl or heteroaryl halide/pseudohalide is reacted with CO and a compound according to the formula HNu, wherein Nu is H (“reductive carbonylation”), —OR, —NR₂ or a similar radical. The reaction is conducted in the presence of the Pd catalyst and a base. The Pd catalyzed carbonylation is an effective method for the synthesis of carbonyl compounds, such as aldehydes, esters, and amides, and is of high interest to the chemical industry as its products are valuable intermediate products for the preparation of herbicides and pharmaceuticals. (j) Heck coupling of aryl, heteroaryl or vinyl halides/pseudohalides to olefins. The reaction is conducted in the presence of the Pd catalyst and a base. As the olefin substrate tolerates a lot of different functionalities, such as ester, ether, carboxy, cyano, and hydroxyl groups, the Heck coupling is one of the most important methods to form C—C bonds.

An example of a C—N coupling reaction is the Buchwald-Hartwig coupling of an aryl or heteroaryl halide/pseudohalide with an amine (Buchwald-Hartwig amination). The amine component can be varied broadly, it includes various secondary and primary alkyl (including cycloalkyl) amine and anilines. The reaction is conducted in the presence of the Pd catalyst and a base. The Buchwald-Hartwig amination is an effective tool for the synthesis of aniline derivatives that play an important role in the preparation of pharmaceuticals, agro chemicals, and in photography.

An example of a reaction resulting in the formation of a C—O bond is the coupling of an aryl or heteroaryl halide/pseudohalide with an alcohol. The Pd catalyzed C—O coupling may be used for substrates that do not couple in the absence of the Pd catalyst under “normal” conditions of the well-known electrophilic substitution. Preferably, the alkoxide employed is NaOtBu or a phenoxide. The reaction is conducted in the presence of the Pd catalyst (and a base, in case the alcohol is employed instead of the alkoxide). The resulting diaryl and arylalkyl ethers play an important role in the synthesis of pharmaceuticals and natural products.

The term “pseuodhalogen” or “pseudohalide” has the standard meaning accepted in the art. Non-limiting examples of pseudohalogens/pseudohalides are —COCl, —SO₂C1, —N₂X, —OP(O) (OR)₂, —OSO₂CF₃ (—OTf, triflate), and —OSO₂Tol (—OTs, tosylate). The preferred pseudohalides used in the above coupling reactions are the triflates.

The above-mentioned coupling reactions are preferably conducted by using the corresponding chlorides, bromides, or triflates as starting materials, more preferably the corresponding chlorides or bromides are used.

It is understood that the above list of coupling reactions is not limiting and it is immediately evident to the person skilled in the art that the present catalysts can be used in similar coupling reactions.

A further example of a reaction that can be catalyzed the by the catalysts according to the present invention is the dehydrohalogenation, especially dehydrochlorination, of aryl and heteroaryl halides, preferably chlorides and bromides. The dehalogenation of aryl and heteroaryl halides is not only important for the organic synthesis but also for environmental chemistry as the dechlorination of polychlorinated biphenyls (PCB) and related chlorinated arenes represents a mechanism to detoxicate these persistent harmful substances. Although the heterogeneous Pd catalyzed dehalogenation has been used for may years, the new phosphine compounds used as ligands in homogeneous transition metal complexes, preferably Pd complexes, offer a new perspective to dehalogenate aryl and heteroaryl halides under mild conditions.

It is a matter of fact that a transition metal complex comprising a specific phosphine compound as a ligand has not the same effectiveness as catalyst in all different types of reactions with all different types of substrates. A significant advantage of the new phosphine compounds is that they have a variable backbone they allows “catalyst fine tuning”, i.e. detailed structural and electronic modifications in order to adapt the ligand to the intended use. Especially the fluorenyl-substituted phosphine compounds can be varied readily: Substituents at the 1- and 8-positions (R¹¹ and R¹⁸) allow to modulate the steric bulk close to the phosphorous atom and the 2- and 7-positions (R¹² and R¹⁷) allow the easy introduction of the various functional groups. It is within the ordinary skill of an organic chemist to conduct some routine experiments in order to find out which specific phosphine compound according to the present invention will be the appropriate ligand in a transition metal catalyst to function as an highly effective catalyst for the preparation of a selected product. In general, reactions using the present catalysts produce the desired products in high yield, with high catalytic productivity, and/or with high purity. In many cases, the new catalysts possess the ability to employ the less reactive, but cost-effective chlorides.

The following examples illustrate the preparation of the new phosphine compounds and/or their corresponding phosphonium salts. The exemplary use of some of the synthesized compounds in various coupling reactions is also illustrated.

EXAMPLES

All chemicals were purchased as reagent grade from commercial suppliers and used without further purification, unless otherwise noted. THF was distilled over potassium and benzophenone under an argon atmosphere, diethylether was distilled over sodium/potassium alloy and benzophenone under an argon atmosphere. Diisopropylamine was dried over potassium hydroxide, dioxane was dried over calcium hydride. Proton (¹H NMR), carbon (¹³C NMR) and phosphorus (³¹P NMR) nuclear magnetic resonance spectra were recorded on Bruker DRX 500 at 500 MHz, 125.75 MHz and 202.46, respectively or on Bruker DRX 300 at 300 MHz and 75.07 MHz respectively. The chemical shifts are given in parts per million (ppm) on the delta scale (δ) and are referenced to tetramethylsilane (δ=0 ppm), ¹H NMR and 65% aq. H₃PO₄. (δ=0 ppm). ³¹P NMR. Abbreviations for NMR data: s=singlet; d=doublet; t=triplet; q=quartet; dd=doublet of doublets; dt=doublet of triplets; dq=doublet of quartets; tt=triplet of triplets; m=multiplet. IR-spectra were recorded on Perkin Elmer 1600 series FT-IR. Mass spectra were recorded on a Finigan MAT 95 magnetic sector spectrometer. Thin layer chromatograpy (TLC) was performed using Fluka silica gel 60 F 254 (0.2 mm) on aluminum plates. Silica gel columns for chromatography were prepared with E. Merck silica gel 60 (0.063-0.20 mesh ASTM). Fluorene was purchased from Aldrich and used as received.

The radicals R, R₁, R₂, etc. do not have the same meanings as defined in the general part of the description, but the meanings as evident from the examples.

A. PREPARATION OF PHOSPHINE COMPOUNDS I. Preparation of Cyclopentadienyl Phosphonium Salts

General procedure for the synthesis of Cp* phosphonium salts:

Synthesis of Cp*PCy₂.HBF₄ (14a)

In a 250 ml Schlenk flask pentamethylcyclopentadiene (HCp*) (2.9 g, 21.3 mmol) was dissolved in diethylether, abs (100 ml) and treated with n-BuLi (8.1 ml, 2.5 M in hexane, 20.3 mmol) at −60° C. The mixture was stirred for 4 h at ambient temperature, to give a thick white suspension. THF, abs (100 ml) was added and the suspension was quenched with Cy₂PCl (3.93 g, 16.9 mmol) at −60° C. The reaction mixture was stirred at ambient temperature overnight, then filtered over a small pad of Celite® filter aid using a Schlenk technique. The clear, colorless filtrate was then quenched with HBF₄.Et₂O (2.7 ml, 19.9 mmol) which led to precipitation of the phosphonium salt as a white solid about 3 minutes after the addition of the acid. The solid was separated via suction filtration, washed with Et₂O, and the volatiles removed in vacuo to afford 14a as a white solid (3.7 g, 52%).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 6.06 (dt, ¹J=470 Hz, ³J=4 Hz 1H, PH), 2.15-2.07 (m, 2H, CH), 2.03-1.99 (m, 2H, CH₂), 1.98 (s, 6H, CH₃), 1.89 (d, ⁴J(PH)=3.5 Hz, 6H, CH₃), 1.89-1.85 (m, 6H, CH₂), 1.73-1.56 (m, 6H, CH₂), 1.51 (d, ³J(PH)=17.5 Hz, 3H, CH₃), 1.32-1.25 (m, 6H, CH₂); ¹³C{¹H} NMR (125.75 MHz, CDCl₃) δ [ppm] 142.7 (d, ^(P-C)J=6.8 Hz), 134.8, 55.1 (d, ^(P-C)J=28.3 Hz), 30.3, 30.0, 29.6 (d, ^(P-C)J=3.5 Hz), 28.5 (d, ^(P-C)J=3.4 Hz), 26.9 (d, ^(P-C)J=11.9 Hz), 26.7 (d, ^(P-C)J=13.6 Hz), 25.0, 17.3 (d, ^(P-C)J=3.3 Hz), 11.4 (d, ^(P-C)J=22.1 Hz); ³¹P{¹H} NMR (202.45 MHz, CDCl₃) δ [ppm] 26.7; ³¹P NMR (202.45 MHz, CDCl₃) δ [ppm] 26.7 (d, ^(P-H)J=471.5 Hz).

Synthesis of Cp*PiPr₂.HBF₄ (15a)

In a 250 ml Schlenk flask pentamethylcyclopentadiene (HCp*) (2.79 g, 20.5 mmol) was dissolved in diethylether, abs (175 ml) and treated with n-BuLi (7.8 ml of a 2.5 M solution in hexane, 19.5 mmol) at −60° C. The mixture was stirred for 4 h at ambient temperature (magnetic stirrer), to result in a thick white suspension. THF, abs (50 ml) was added, followed by iPr₂PCl (2.48 g, 16.25 mmol) at −60° C. The reaction mixture was stirred at ambient temperature overnight, filtered over a small pad of Celite®. The clear, colorless filtrate was quenched with HBF₄.Et₂O (2.76 ml, 20.3 mmol) which led to precipitation of the phosphonium salt as a white solid. The solid was separated via suction filtration, washed with Et₂O, and the volatiles removed in vacuo to afford 15a as a white solid (5.2 g, 94%).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 6.21 (dt, ¹J=468.5 Hz, ³J=4.5 Hz 1H, PH), 2.52-2.43 (m, 2H, CH), 2.00 (s, 6H, CH₃), 1.89 (d, ⁴J(PH)=3.0 Hz, 6H, CHA, 1.51 (d, ³J(PH)=17.5 Hz, 3H, CH₃), 1.47 (dd, ³J(PH)=18.5 Hz, ³J=7.0 Hz, 6H, CH₃), 1.38 (dd, ³J(PH)=18 Hz, ³J=7.5 Hz, 6H, CH₃); ¹³C{¹H} NMR (125.75 MHz, CDCl₃) δ [ppm] 143.2 (d, ^(P-C)J=6.7 Hz), 135.0, 55.2 (d, ^(PC)J=29.2 Hz), 20.8 (d, ^(PC)J=38.4 Hz), 20.1 (d, ^(P-C)J=2.5 Hz), 18.8 (d, ^(P-C)J=3.3 Hz), 18.1 (d, ^(P-C)J=3.4 Hz), 11.8 (d, ^(P-C)J=39.4 Hz); ³¹P{¹H} NMR (202.45 MHz, CDCl₃) δ [ppm] 34.9; ³¹P NMR (202.45 MHz, CDCl₃) δ [ppm] 34.9 (d, ^(P-H)J=469.3 Hz).

II. Preparation of indenyl derivatives and precursors Synthesis of Tigloyl Chloride (33)

Tiglic acid (32) (100.0 g, 1.00 mol) and thionyl chloride (178.4 g, 1.5 mol) were placed in a 500 ml round bottomed flask fitted with a magnetic stirring apparatus and a reflux condenser. The mixture was refluxed until the development of HCl gas was completed. Then the reflux condenser was replaced by a distillation head. Excess of thionyl chloride was removed at 100-130° C. at ambient pressure, followed by tigloyl chloride (33) (106.32 g, 1.06 mol, 89%) as a colorless liquid at 140-145° C. The ¹H NMR spectrum was identical with the literature (T. E. Ready, J. C. W. Chien, M. D. Rausch, J. Org. Chem. 1999 583, 11-27; B. B. Snider, Q. Che, Org. Lett. 2004, 6, 17, 2877-2880).

¹H NMR (200 MHz, CDCl₃): δ [ppm] 7.33 (q, ³J=6.3 Hz, 1H, CH), 1.93 (d, ³J=9.7 Hz, 3H, CH₃CH), 1.91 (s, 3H, CH₃).

Synthesis of 2,3-dimethyl-1-indanone (34)

Under an argon atmosphere benzene (335 ml, 3.74 mol) and aluminum trichloride (90.78 g, 0.68 mol) were introduced into a 1 liter three necked round bottomed flask fitted with a magnetic stirring apparatus, an addition funnel and a reflux condenser. The stirred orange mixture was cooled to 7° C. and tigloyl chloride (33) (40 g, 0.34 mol) was added dropwise via an addition funnel. After completion of the addition, the mixture was allowed to come to room temperature and then refluxed overnight. Then the reaction mixture was allowed to come to room temperature and poured onto mixture of ice (300 g) and conc. HCl (50 ml). The organic layer was separated and washed with a saturated solution of sodium bicarbonate (3×100 ml), then dried over magnesium sulfate and filtered. The excess benzene was removed under reduced pressure to afford (34) (50.02 g, 92%) as a yellow liquid. The ¹H NMR spectrum was identical with the literature (T. E. Ready, J. C. W. Chien, M. D. Rausch, J. Org. Chem. 1999 583, 11-27; J. Sarrazin, A. Tallec, Tetrahedron Letters, 1977, 18, 1579-1582; M. Hiscock, G. B. Porter, J. Chem. Soc. (B), 1971, 1631-1634).

¹H NMR (200 MHz, CDCl₃): δ [ppm] 7.76-7.34 (m, 4H, arom), 2.94 (dq, ³J=4.9 Hz, ³J=7.0 Hz, 1H, H-position 2), 2.24 (dq, ³J=7.3 Hz, ³J=4.7 Hz, 1H, H-position 3), 1.46 (d, ³J=6.9 Hz, 3H, CH₃-position 2), 1.32 (d, ³J=7.3 Hz, 3H, CH₃-position 3).

Synthesis of 2,3,4,7-tetramethyl-1-indanone (35)

Under an argon atmosphere AlCl₃ (64 g, 0.48 mol) and CS₂ (250 ml) were placed in a 1 liter three necked round bottomed flask fitted with a magnetic stirring apparatus, an addition funnel, an inner thermometer and a reflux condenser. A mixture of tigloyl chloride (33) (42 g, 0.35 mol) and p-xylene (42.8 ml, 0.35 mol) was added over a period of 1 h at −10° C. under vigorous stirring. After 2 h stirring at −10° C. the mixture was allowed to come to ambient temperature and was stirred at that temperature overnight. The brown reaction mixture was then refluxed for 3 h, after cooling to ambient temperature the reaction mixture was poured carefully onto a mixture of concentrated HCl (300 ml) and ice (500 g). Then the mixture was transferred into a separation funnel, the lower CS₂ layer was separated and the aqueous layer extracted with diethyl ether (3×100 ml). The combined organic layers were dried over magnesium sulfate, filtered, and the solvents removed in a rotary evaporator to give a red brown liquid. This residue was rectified using a 35 cm Vigreux column to afford 2,3,4,7-tetramethyl-1-indanone (35) (34 g, 52%, 95-100° C., 1.5-1.2 mbar) as a pale yellow liquid. (35) was found to be a mixture of the two isomers of 2,3,4,7-tetramethyl-1-indanone (35a to 35b approximately 3:1). The ¹H NMR spectrum was identical with the literature (S. Barlow, D. R. Cary, M. J. Drewitt, D. O'Hare, J. Chem. Soc. Dalton Trans. 1997 3867-3878).

¹H NMR: (300 MHz, CDCl₃): δ [ppm] 35a δ 7.23 (d, ³J=7.5 Hz, 1H, arom), 7.02 (d, ³J=7.5 Hz, 1H, arom), 2.96 (qd., ³J=7.2 Hz, ³J=2.4 Hz, 1H, CH-position 2), 2.59 (s, 3H, benzylic CHA, 2.37 (s, 3H, benzylic CH₃), 2.25 (qd, ³J=7.5 Hz, ³J=2.4, 1H, CH-position 3), 1.34 (d, ³J=7 Hz, 3H, CHCH₃-position 2), 1.26 (d, ³J=7.2 Hz, 3H, CHCH₃-position 3); 35b δ 7.22 (d, ³J=7.5 Hz, 1H, arom), 7.01 (d, ³J=7.5 Hz, 1H, arom), 3.48 (qui, ³J=7.2 Hz, 1H, CH-position 2), 2.77 (qui, ³J=7.5 Hz, 1H, CH-position 3), 2.59 (s, 3H, benzylic CHA, 2.37 (s, 3H, benzylic CH₃), 1.24 (d, ³J=7.5 Hz, 3H, CHCH₃-position 2), 1.09 (d, ³J=7.2 Hz, 3H, CHCH₃-position 3).

Synthesis of 4,7-dimethoxy-2,3-dimethyl-1-indanone (36)

AlCl₃ (64 g, 0.48 mol) and CH₂Cl₂ (250 ml) (dried with magnesium sulfate) were placed under an argon atmosphere in a 500 ml three necked round bottomed flask fitted with a magnetic stirring apparatus, an addition funnel, an inner thermometer and a reflux condenser. A mixture of tigloyl chloride (33) (42 g, 0.35 mol) and 1,4-dimethoxybenzene (48.4 g, 0.35 mol, dissolved in CH₂Cl₂ (75 ml)) was added over a period of 1 h at −10° C. under vigorous stirring. After 2 h stirring at −2° C. to −5° C. the mixture was allowed to come to ambient temperature and was stirred overnight. The dark red mixture was then refluxed for 2 h, after cooling to ambient temperature the reaction mixture was poured carefully onto a mixture of concentrated HCl (300 ml) and ice (500 g). Then the resulting yellow mixture was transferred to a separation funnel, the lower CH₂Cl₂ layer was isolated and the aqueous layer extracted with diethyl ether (3×100 ml). The combined organic layers were dried over magnesium sulfate, filtered, and the solvents removed under reduced pressure to give a dark brown liquid. This residue was distilled using a 15 cm Vigreux column to obtain an orange-yellow light viscous liquid (110-115° C., 0.8 mbar). The liquid was purified via column chromatography [(SiO₂, 25×9 cm) eluent: cyclohexane:ethylacetate (1:1)] to afford 2,3-dimethyl-4,7-dimethoxy-1-indanone (36) (9.53 g, 12%), R_(f) 0.35 (cyclohexane:ethylacetate (5:1)) as an orange liquid. The liquid was found to be a mixture of the two isomers of 4,7-dimethoxy-2,3-dimethyl-1-indanone (36a to 36b approximately 4:1).

¹H NMR: (500 MHz, CDCl₃): 36a δ [ppm] 7.01 (d, ³J=8.0 Hz, 1H, arom), 6.74 (d, ³J=8.5 Hz, 1H, arom), 3.89 (s, 3H, O—CHA, 3.84 (s, 3H, O—CH₃), 2.97 (qd, ³J=7.0 Hz, ³J=3.0 Hz, 1H, CH-position 2), 2.22 (qd, ³J=7.5 Hz, ³J=3.0 Hz, 1H, CH-position 3), 1.40 (d, ³J=7.0 Hz, 3H, CHCHA, 1.26 (d, ³J=7.5 Hz, 3H, CHCH₃); 36b δ [ppm] 6.99 (d, ³J=9.0 Hz, ¹H, arom), 6.72 (d, ³J=7.5 Hz, 1H, arom), 3.89 (s, 3H, O—CH₃), 3.86 (s, 3H, O—CH₃), 3.53 (pseudo-quintet, ³J=7.5 Hz, 1H, CH-position 2), 2.74 (qui, ³J=7.5 Hz, 1H, CH-position 3), 1.20 (d, ³J=7.0 Hz, 3H, CHCH₃-position 2) 1.16 (d, ³J=7.0 Hz, 3H, CHCH₃-position 3); ¹³C{¹H}(125.77 MHz, CDCl₃): δ [ppm] 36a 207.2, 151.8, 150.9, 148.2, 124.8, 117.5, 109.8, 56.0, 55.8, 51.6, 39.8, 19.5, 16.2; 36b 206.5, 151.5, 150.3, 149.3, 124.8, 116.9, 109.7, 56.0, 55.8, 47.1, 34.5, 16.1, 14.2.; HRMS: Calcd.: 220.1099. found: 220.10909.

Synthesis of 1,2,3-trimethylindene (37)

In a 1 liter three necked round bottomed flask fitted with a magnetic stirring apparatus and a reflux condenser 2,3-dimethyl-1-indanone (34) (19.2 g, 0.12 mol) was dissolved in dry diethyl ether (300 ml) under an argon atmosphere. Methyllithium (46.3 ml, 3 M solution in diethoxymethane, 0.14 mol) was added dropwise via a syringe and the mixture was refluxed overnight. The mixture was cooled to 0° C. and a solution of saturated ammonium chloride (100 ml) was added dropwise through the top of the condenser. The mixture was transferred into a separation funnel, the organic layer was washed with water (3×100 ml), dried over magnesium sulfate and filtered. The ether was removed under reduced pressure to afford the raw 1,2,3-trimethyl-1-indanol (19.34 g, 92%) as a yellow liquid which was used for the next step without further purification. Toluene (300 ml) was added to the raw 1,2,3-trimethyl-1-indanol (19.34 g, 0.11 mol) and the solution was transferred into a 500 ml round bottomed flask fitted with a Dean-Stark trap and a magnetic stirring apparatus. p-Toluene sulfonic acid (50 mg, 0.26 mmol) was added and the solution refluxed overnight. After completion of the removal of the water the excess toluene was removed via distillation through the Dean-Stark arm, the residue was cooled to ambient temperature, diluted with diethyl ether (100 ml), washed with a saturated solution of sodium bicarbonate (3×100 ml), dried over magnesium sulfate and filtered. After removal of the solvent in vacuo, the liquid was purified via column-chromatography [(SiO₂, 50×9 cm) eluent: cyclohexane:ethylacetate (10:1)] to afford two fractions: 1,2,3-Trimethylindene (37) (8.92 g, 51%) as a pale yellow liquid R_(f) 0.41; (34) (7.94 g, 45%) (starting material) was obtained as a dark yellow liquid.

¹H NMR: (500 MHz, CDCl₃): δ [ppm] 7.34-7.10 (m, 4H, arom), 3.17 (q, ³J=7.5 Hz, 1H, H-position 1), 2.01 (q, ⁵J=1.0 Hz, 3H, CH₃-position 2), 1.97 (q, ⁵J=1.0 Hz, 3H, CH₃-position 3), 1.26 (d, ³J=7.5 Hz, 3H, CH₃-position 1); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 148.6, 146.6, 143.5, 131.4, 126.7, 124.2, 122.5, 118.3, 47.3, 16.1, 12.3, 10.5.

Synthesis of 1,2,3,4,7-pentamethylindene (38)

In a 1 liter three necked round bottomed flask fitted with a magnetic stirring apparatus and a reflux condenser 2,3,4,7-tetramethyl-1-indanone (35) (19.52 g, 0.1 mol) was dissolved in dry diethyl ether (300 ml) under an argon atmosphere. The mixture was cooled with ice and methyllithium (45 ml, 3 M solution in diethoxymethane, 0.135 mol) was added dropwise via a syringe, then the mixture was refluxed for 3 h. When the yellow reaction mixture had cooled a mixture of concentrated HCl (20 ml) and H₂O (60 ml) was added via an addition funnel. The resulting mixture was transferred to a separation funnel and extracted with diethyl ether (3×200 ml). The combined organic layers were stirred overnight with 15 ml concentrated HCl. After this time the reaction mixture was carefully adjusted to pH 7 with a saturated aqueous solution of sodium carbonate. The reaction mixture was transferred into a separation funnel. The organic layer was washed with H₂O (3×100 ml), dried over MgSO₄, filtered and the solvent removed under reduced pressure to give a yellow liquid. This residue was purified via column-chromatography [(SiO₂, 25×9 cm) eluent: cyclohexane] to afford 1,2,3,4,7-pentamethylindene (38) (8.35 g, 44%) as a yellow liquid; then (35) (starting material) (9.60 g, 49%) (eluent: cyclohexane:ethylacetate (10:1)) as a yellow liquid.

¹H NMR: (500 MHz, CDCl₃): δ [ppm] 6.88 (d, ³J=7.5 Hz, 1H, arom), 6.78 (d, ³J=8.0 Hz, 1H, arom), 3.15 (q, ³J=7.5 Hz, 1H, CH), 2.54 (s, 3H, benzylic CH₃), 2.35 (s, 3H, benzylic CH₃), 2.19 (q, ⁵J=1.0 Hz, 3H, CH₃-position 2), 1.94 (q, ⁵J=1.0 Hz, 3H, CH₃-position 3) 1.23 (d, ³J=7.5 Hz, 3H, CHCH₃); ¹³C{H₁} NMR (125.77 MHz, CDCl₃) δ [ppm] 146.8, 143.3, 143.2, 132.1, 129.9, 129.6, 127.5, 125.6, 46.3, 20.0, 18.6, 14.7, 14.1, 12.0.

Synthesis of 4,7-dimethoxy-1,2,3-trimethylindene (39)

Diethyl ether (100 ml) and magnesium turnings (0.96 g, 39 mmol) were placed in a 250 ml three necked round bottomed flask fitted with a magnetic stirring apparatus and a reflux condenser. Under an argon atmosphere a solution of CH₃I (2.66 ml, 43 mmol) in degassed and dried diethyl ether (50 ml) was added via an addition funnel. The resulting grey solution was stirred for 45 min before addition of dry light petroleum (b.p. 80-110° C.) (20 ml). The ether was then removed under reduce pressure to yield a grey suspension. The resulting mixture was cooled with ice and a solution of 2,3-dimethyl-4,7-dimethoxy-1-indanone (36) (7 g, 32 mmol) in pentane (50 ml) was added dropwise over a period of 40 min, then the mixture was refluxed for 3 h. Then the yellow reaction mixture was cooled to 0° C. and a mixture of HCl (10 ml) and H₂O (40 ml) was added via an addition funnel. The resulting solution was transferred into a separation funnel and extracted with diethyl ether (3×50 ml). The combined organic layers were then washed with 0.25 M aqueous sodium thiosulfate (3×30 ml). The organic layers were filtered into a round bottomed flask, 15 ml concentrated HCl were added and the mixture was stirred at ambient temperature overnight. Then pH 7 was adjusted by addition of a saturated aqueous solution of sodium carbonate. The mixture was transferred into a separation funnel. The organic layer was washed with water (3×100 ml), dried over MgSO₄, filtered and the solvent removed under reduced pressure.

The residual liquid was purified via column chromatography [(SiO₂, 35×9 cm), initial eluent: cyclohexane:ethylacetate (100:2))] to afford two fractions: 1,2,3-trimethyl-4,7-dimethoxyindene (39) (4.63 g, 66%) as a yellow liquid R_(f) 0.42; (Change of eluents to cyclohexane:ethylacetate (2:1)): 4,7-dimethoxy-2,3-dimethyl-1-indanone (36) (starting material) R_(f) 0.35 (cyclohexane:ethylacetate) (5:1)) as a pale yellow liquid.

¹H NMR: (500 MHz, CDCl₃): δ [ppm] 6.70 (d, ³J=8.5 Hz, ¹H, arom), 6.56 (d, ³J=9 Hz, 1H, arom), 3.80 (s, 3H, O—CH₃), 3.78 (s, 3H, O—CH₃) 3.23 (q, ³J=7.5 Hz, 1H, CH), 2.17 (s, 3H, CH₃), 1.90 (s, 3H, CH₃) 1.23 (d, ³J=7 Hz, 3H, CHCH₃); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 150.6, 149.1, 142.9, 137.2, 135.7, 131.1, 111.1, 107.5, 56.7, 56.0, 46.4, 14.7, 13.4, 12.0. HRMS: Calcd.: 218.1306. found: 218.13110.

III. Preparation of Indenyl Phosphonium Salts Synthesis of 1,2,3-trimethylindenyl-dicyclohexyl-phosphonium-trifluoroborate (16a)

In a 100 ml Schlenk 1,2,3-trimethylindene (37) (2.44 g, 15.4 mmol) was dissolved in Et₂O (50 ml) under an argon atmosphere. The mixture was cooled to −60° C. (N₂/Isopropanol) and n-BuLi (5.9 ml, 2.5 M solution in hexane, 14.7 mmol) was added. The solution was stirred for 10 min at −60° C., then for 3 hours at ambient temperature. A white precipitate was formed. Then the mixture was cooled to −60° C. and Cy₂PCl (2.7 ml, 12 mmol) was added. The mixture was allowed to come to room temperature, stirred for additional 2 h and the formed LiCl was removed by filtration over a pad of Celite® under Schlenk conditions. The resulting slightly yellowish filtrate was treated dropwise with HBF₄.Et₂O (2 ml, 14.9 mmol) to give a white precipitate which was separated via filtration and dissolved in 10 ml acetonitrile. After filtration the clear filtrate was dropped into Et₂O (900 ml, vigorously stirred). The formed white precipitate was separated via suction filtration. Removal of the volatiles in vacuo afforded (16a) as a white solid (2.82 g, 53%). ¹H NMR: (500 MHz, CDCl₃): δ [ppm] 7.64 (d, ³J=7.5 Hz, 1H, arom), 7.48 (t, ³J=7.5 Hz, 1H, arom), 7.40-7.35 (m, 2H, arom), 6.36 (dt, J(P)=475 Hz, ⁴J=3.5 Hz, 1H, P—H), 2.34-2.26 (m, 1H, —CH), 2.16 (d, ⁴J(P)=4.0 Hz, 3H, CH₃-position 2), 2.14 (s, 3H, CH₃-position 3), 2.09-1.14 (m, 21H, CH₂ and —CH), 1.81 (d, ³J(P)=17.5 Hz, 3H, CH₃-position 1);

¹³C{¹H}(125.77 MHz, CDCl₃): δ [ppm] 145.2, 141.8, 138.8 (d, J=7.8), 137.8 (d, J=2.9 Hz), 129.8, 126.7, 123.4, 120.0, 51.6 (d, J=32.2 Hz), 31.0, 30.7 (d, J=10.8 Hz), 30.5, 29.8 (d, J=3 Hz), 29.0 (d, J=3.5 Hz), 28.2 (d, J=3.3 Hz), 28.1 (d, J=3.1 Hz), 26.9 (d, J=6.0 Hz), 26.8 (d, J=5.8 Hz), 26.6, 26.5, 24.9 (d, J=3.8 Hz), 19.6, 11.2, 10.7; ³¹P CHI (202.46 MHz, CDCl₃): δ [ppm] 29.2; ³¹P (202.46 MHz, CDCl₃): δ [ppm] 29.2 (d, J=473.7 Hz).

Synthesis of 1,2,3-tetramethylindenyl-diisopropyl-phosphonium-trifluoroborate (17a)

In a 250 ml Schlenk flask fitted with stirring apparatus 1,2,3-trimethylindene (37) (5.14 g, 32.5 mmol) was dissolved in Et₂O (100 ml) under an argon atmosphere. The mixture was cooled to −60° C. (N₂/Isopropanol) and n-BuLi (12.38 ml, 2.5M solution in hexane, 31 mmol) was added. The solution was stirred for 10 min at −60° C., then for 3 hours at ambient temperature. A white precipitate was formed. Then the mixture was cooled to −60° C. and iPr₂PCl (4.1 ml, 25.8 mmol) was added. The mixture was allowed to come to room temperature, stirred for additional 2 h and the formed LiCl was removed by filtration over a pad of Celite® under Schlenk conditions. The resulting slightly yellowish filtrate was treated dropwise with HBF₄.Et₂O (4.42 ml, 32 mmol) to give a white precipitate which was separated via filtration and dissolved in 10 ml acetonitrile. After filtration the clear filtrate was dropped into Et₂O (900 ml, vigorously stirred). The formed white precipitate was separated via suction filtration. Removal of the volatiles in vacuo afforded (17a) as a white solid (8.53 g, 91%) ¹H NMR: (500 MHz, CDCl₃): δ [ppm] 7.68 (d, ³J=8.0 Hz, 1H, arom), 7.48 (t, ³J=7.5 Hz, 1H, arom), 7.39-7.35 (m, ²H, arom), 6.44 (dt, ¹J(P)=473, ³J=4.0 Hz, 1H, P—H), 2.69 (m, 1H, —CH), 2.41 (m, 1H, —CH), 2.16 (s, 3H, CH₃-position 3), 2.15 (d, ³J=3.5 Hz, 3H, CH₃-position 2), 1.81 (d, ³J(P)=17 Hz, 3H, CH₃-position 1), 1.44 (ddd, ³J(P)=96.0 Hz, ³J=18.5 Hz, ³J=7.5 Hz, 6H, CH₃) 1.13 (ddd, ³J(P)=91.0 Hz, ³J=18.0 Hz, J=7.0 Hz, 6H, CH₃); ¹³C{¹H}(125.77 MHz, CDCl₃): δ [ppm] 145.1 (d, J=3.8 Hz), 141.6, 138.9 (d, J=8.0 Hz), 137.7 (d, J=3.8 Hz), 129.8, 126.7, 123.5 (d, J=3.5 Hz), 120.2, 51.5 (d, J=32.6 Hz), 21.1 (d, J=6.7 Hz), 20.8 (d, J=5.6 Hz), 19.9 (d, J=11.5 Hz), 19.1 (d, J=2.1 Hz), 18.2 (d, J=2.3 Hz), 17.7 (d, J=2.3 Hz), 11.1, 10.8.; ³¹P {¹H} (202.46 MHz, CDCl₃): δ [ppm] 36.6; ³¹P (202.46 MHz, CDCl₃): δ [ppm] 36.6 (d, J=472.9 Hz).

Synthesis of 1,2,3,4,7-pentamethylindenyl-diisopropyl-phosphonium-trifluoroborate (19a)

In a 100 ml Schlenk flask 1,2,3,4,7-pentamethylindene (38) (3.0 g, 16 mmol) was dissolved in Et₂O (50 ml) under an argon atmosphere. The mixture was cooled to −60° C. (N₂/Isopropanol) and n-BuLi (16.1 ml, 2.5M solution in hexane, 15 mmol) was added. The solution was stirred for 10 min at −60° C., then for 3 hours at ambient temperature. A white precipitate was formed. The mixture was cooled to −60° C. and iPr₂PCl (2.0 ml, 12.8 mmol) was added. The mixture was allowed to come to room temperature, stirred for additional 2 h and the formed LiCl was removed by filtration over a pad of Celite® under Schlenk conditions. The resulting slightly yellowish filtrate was treated dropwise with HBF₄.Et₂O (2.2 ml, 16 mmol) to give a white precipitate separated via filtration and dissolved in 10 ml chloroform. After filtration the clear filtrate was dropped into Et₂O (900 ml, vigorously stirred). The formed white precipitate was separated via suction filtration. Removal of the volatiles in vacuo afforded (19a) as a white solid (4.23 g, 84%). ¹H NMR: (500 MHz, CDCl₃): δ [ppm] 7.09 (d, ³J=8.0 Hz, 1H, arom), 6.97 (d, ³J=8.0 Hz, 1H, arom) 6.41 (dq, ¹J(P)=468 Hz, ³J=5.3 Hz, 1H, P—H), 2.84-2.75 (m, 1H, —CH), 2.59 (s, 3H, —CH₃ benzylic), 2.58 (s, 3H, —CH₃ benzylic), 2.31 (d, ⁴J=4.5 Hz, 3H, CH₃-position 2), 2.23-2.14 (m, 1H, —CH), 2.13 (s, 3H, CH₃-position 3), 1.89 (d, ³J(P)=17 Hz, 3H, CH₃-position 1), 1.50 (ddd, ³J(P)=107 Hz, ³J=18.5 Hz, J=7.0 Hz, 6H, CH₃) 1.12 (ddd, ³J(P)=96.5 Hz, ³J=18.5 Hz, J=7.0 Hz, 6H, CH₃); ¹³C{¹H} (125.77 MHz, CDCl₃): δ [ppm] 143.3, 141.4 (d, J=9.2 Hz), 140.6, 136.2 (d, J=6.3 Hz), 133.6, 132.2 (d, J=2.1 Hz), 130.2, 130.0, 52.9 (d, J=29.2 Hz), 22.1 (d, J=3.6 Hz), 21.8, 20.6, 20.4 (d, J=2.3 Hz), 20.2, 19.1 (d, J=1.8 Hz), 18.9 (d, J=1.9 Hz), 18.7 (d, J=1.8 Hz), 18.1 (d, J=3.1 Hz), 15.2, 12.3; ³¹P{¹H} (202.46 MHz, CDCl₃): δ [ppm] 34.0; ³¹P (202.46 MHz, CDCl₃): δ [ppm] 34.0 (d, J=463 Hz).

Synthesis of 1,2,34,7-pentamethylindenyl-dicyclohexyl-phosphonium-trifluoroborate (18a)

In a 100 ml Schlenk flask 1,2,3,4,7-pentamethylindene (38) (3.0 g, 16 mmol) was dissolved in Et₂O (50 ml) under an argon atmosphere. The mixture was cooled to −60° C. (N₂/Isopropanol) and n-BuLi (6.1 ml, 2.5 M solution in hexane, 15 mmol) was added. The solution was stirred for 10 min at −60° C., then for 3 hours at ambient temperature. A white precipitate was formed. Then the mixture was cooled to −60° C. and Cy₂PCl (2.8 ml, 12.7 mmol) was added. The mixture was allowed to come to room temperature, stirred for additional 2 h at ambient temperature and the formed LiCl was removed by filtration over a pad of Celite® under Schlenk conditions. The resulting slightly yellowish filtrate was treated dropwise with HBF₄.Et₂O (2.2 ml, 16 mmol) to give a white precipitate which was separated via filtration and dissolved in 10 ml chloroform. After filtration the clear filtrate was dropped into Et₂O (700 ml, vigorously stirred). The formed white precipitate was separated via suction filtration. Removal of the volatiles in vacuo afforded (18a) as a white solid (4.12 g, 69%).

¹H NMR: (500 MHz, CDCl₃): δ [ppm] 7.10 (d, ³J=8.0 Hz, 1H, arom), 6.97 (d, ³J=8.0 Hz, 1H, arom), 6.30 (dq, ¹J(P)=470 Hz, J=3.5 Hz, 1H, P—H), 2.58 (s, 3H, —CH₃ benzylic), 2.58 (s, 3H, —CH₃ benzylic), 2.46-2.39 (m, 1H, —CH), 2.31 (d, ⁴J(P)=4.5 Hz, 3H, CH₃-position 2), 2.11 (s, 3H, CH₃-position 3), 1.89 (d, ³J(P)=16.5 Hz, 3H, CH₃-position 1), 1.86-0.93 (m, 21H, —CM and —CH); ¹³C{¹H} (125.77 MHz, CDCl₃): δ [ppm] 143.0, 140.9 (d, J=9.3), 140.3, 136.0 (d, J=4.9 Hz), 133.1, 131.9 (d, J=4.0), 129.7, 129.6, 52.8 (d, J=29.2 Hz), 31.5 (d, J=7.2 Hz), 31.2, 29.6 (d, J=3.5 Hz), 29.1 (d, J=3.3 Hz), 28.2 (d, J=3.5 Hz), 27.9 (d, J=3.8 Hz), 27.0 (d, J=11.9 Hz), 26.8, 26.7, 26.6 (d, J=13.1), 25.0, 24.8, 20.2, 19.8, 18.1, 14.8, 11.9.; ³¹P {¹H} (202.46 MHz, CDCl₃): δ [ppm] 25.5; ³¹P (202.46 MHz, CDCl₃): δ [ppm] 25.5 (d, J=472.3 Hz).

Synthesis of 4,7-dimethoxy-1,2,3-trimethylindenyl-dicyclohexyl-phosphonium-trifluoroborate (20a)

In a 100 ml Schlenk flask 4,7-dimethoxy-1,2,3-trimethylindene (39) (1.7 g, 7.79 mmol) was dissolved in Et₂O (50 ml) under an argon atmosphere. The mixture was cooled to −60° C. (N₂/Isopropanol) and n-BuLi (3 ml, 2.5 M solution in hexane, 7.43 mmol) was added. A white precipitate was formed. The solution was stirred for 10 min at −60° C., stirred for 3 hours at ambient temperature. Then the mixture was cooled to −60° C. and Cy₂PCl (1.3 ml, 6.19 mmol) was added. The mixture was allowed to come to room temperature, then for additional 2 h at ambient temperature and the formed LiCl was removed by filtration over a pad of Celite® under Schlenk-conditions. The resulting slightly yellowish filtrate was treated dropwise with HBF₄.Et₂O (1 ml, 7.79 mmol) to give a white precipitate which was separated via filtration and dissolved in 10 ml chloroform. After filtration the clear filtrate was dropped into Et₂O (700 ml, vigorously stirred). The formed white precipitate was separated via suction filtration. Removal of the volatiles in vacuo afforded (20a) as a white solid (1.72 g, 55%).

¹H NMR: (500 MHz, CDCl₃): δ [ppm] 6.93 (dd, ³J=9.0 Hz 1.5 Hz, 1H, arom), 6.77 (d, ³J=9.0 Hz, 1H, arom), 6.24 (ddd, ¹J(P)=472.5, ³J=5.5 Hz, J=2.5 Hz, 1H, P—H), 3.92 (s, 3H, O—CH₃), 3.84 (s, 3H, O—CH₃), 2.60-2.49 (m, 1H, —CH), 2.28 (dd, ⁴J(P)=4.0 Hz, J=1.0 Hz, 3H, —CH₃-position 2), 2.18-2.11 (m, 1H, —CH), 2.06 (s, 3H, —CH₃-position 3), 1.76 (d, ³J(P)=16.5 Hz, 3H, CH₃-position 1), 2.04-1.01 (m, 20H, —CH₂); ¹³C{1H}(125.77 MHz, CDCl₃): δ [ppm] 149.7 (d, J=1.9 Hz), 149.5, 138.9 (d, J=7.0), 136.9 (d, J=3.0 Hz), 134.2 (d, J=2.8), 129.7, 113.8, 109.1, 56.3, 55.7, 51.6 (d, J=32.2 Hz), 32.3, 32.0, 30.6, 30.3, 29.3 (d, J=3.3 Hz), 29.2 (d, J=5.3 Hz), 28.2 (d, J=3.3 Hz), 27.7 (d, J=3.1 Hz), 27.0 (d, J=13.1 Hz), 26.9 (d, J=14.2 Hz), 25.1, 24.9, 17.8, 13.6, 10.7; ³¹P{¹H} (202.46 MHz, CDCl₃): δ [ppm] 25.4; ³¹P (202.46 MHz, CDCl₃): δ [ppm] 25.4 (d, J=471.1 Hz).

Synthesis of 4,7-dimethoxy-1,2,3-trimethylindenyl-diisopropyl-phosphonium-trifluoroborate (21a)

In a 100 ml Schlenk flask 4,7-dimethoxy-1,2,3-trimethylindene (39) (1.7 g, 7.79 mmol) was dissolved in Et₂O (50 ml) under an argon atmosphere. The mixture was cooled to −60° C. (N₂/isopropanol) and n-BuLi (3 ml, 2.5 M solution in hexane, 7.43 mmol) was added. The solution was stirred for 10 min at −60° C., then for 3 hours at ambient temperature. A white precipitate was formed. Then the mixture was cooled to −60° C. and iPr₂PCl (1 ml, 6.24 mmol) was added. The mixture was allowed to come to room temperature, stirred for additional 2 h at ambient temperature and the formed LiCl was removed by filtration over a pad of Celite® under Schlenk conditions. The resulting slightly yellowish filtrate was treated dropwise with HBF₄-Et₂O (1 ml, 7.72 mmol) to give a white precipitate which was separated via filtration and dissolved in 10 ml chloroform. After filtration the clear filtrate was dropped into Et₂O (700 ml, vigorously stirred). The formed white precipitate was separated via suction filtration. Removal of the volatiles in vacuo afforded (21a) as a white solid (1.73 g, 66%).

¹H NMR: (500 MHz, CD₃CN): δ [ppm] 7.13 (dd, ³J=9.0 Hz, J=1.5 Hz, 1H, arom), 6.99 (d, ³J=9.0 Hz, 1H, arom), 6.39 (dq, ¹J(P)=465.5 Hz, ³J=3.0 Hz, 1H, P—H), 3.99 (s, 3H, O—CH₃), 3.87 (s, 3H, O—CH₃), 3.10-3.00 (m, 1H, —CH), 2.62-2.51 (m, 1H, CH), 2.30 (dd, ⁴J(P)=5.0 Hz, J=1.0 Hz, 3H, —CH₃-position 2), 2.13 (s, 3H, —CH₃-position 3), 1.86 (d, ³J(P)=16.5 Hz, 3H, CH₃-position 1), 1.45 (ddd, ³J(P)=100 Hz, ³J=19 Hz, ³J=7.0 Hz, 6H, CHA, 1.18 (ddd, ³J(P)=72.5 Hz, ³J=17.5 Hz, ³J=7 Hz, 6H, CH₃); ¹³C{¹H}(125.77 MHz, CD₃CN): δ [ppm] 150.8 (d, J=2.1 Hz), 150.4, 139.7 (d, J=9.0 Hz), 137.6 (d, J=3.4 Hz), 134.7 (d, J=3.5 Hz), 130.5, 115.0, 110.5, 56.6, 56.1, 52.4 (d, J=31.8 Hz), 23.4 (d, J=35.8 Hz), 21.3 (d, J=39.5 Hz), 19.9 (d, J=2.64 Hz), 19.5 (d, J=1.9 Hz), 19.0 (d, J=2.9 Hz), 18.3 (d, J=2.0 Hz), 17.7 (d, J=2.3 Hz), 13.8, 10.8; ³¹P {¹H} (202.46 MHz, benzene d₆): δ [ppm] 33.0; ³¹P (202.46 MHz, benzene d₆): δ [ppm] 33.0 (d, J=464.8 Hz).

IV. Preparation of Fluorenyl Derivatives (i) Preparation of 9-Substituted Fluorenes

General procedure for the synthesis of 9-substituted fluorenes:

To a solution of fluorene (30 mmol) in THF (60 ml), abs, 40 mmol of n-BuLi (2.5 M in hexane) were added at −60° C. The solution immediately turned brownish and was stirred for 1.5 h at room temperature. After cooling to −60° C. again, the reaction mixture was quenched with alkylhalide RX (45 mmol, 1.5 equiv.), stirred for 10 min at −60° C., then additional 2 h at room temperate. 100 ml water were added to the reaction mixture which was then extracted with diethylether (3×100 ml). The combined organic phases were subsequently washed with an aqueous solution of Na₂S₂O₃, brine and dried over MgSO₄. After filtration and removal of the volatiles under vacuum the crude product was purified via filtration on a short silica gel pad (5 cm, eluent: cyclohexane) and concentrated under vacuum resulting in the pure 9-substituted fluorenes typically in near quantitative yield.

The following 9-substituted fluorenes were prepared according to the above general procedure:

9-Methylfluorene (40)

Fluorene (15.0 g, 90.4 mmol), n-BuLi (48.1 ml, 120 mmol, 2.5 M in hexane), RX=iodomethane (19.3 g, 136 mmol). 40 was isolated as a yellowish waxy solid (16.2 g, quant.). The analytical data were identical to those in the literature (M. A. Schmidt, H. G. Alt, W. Milius, J. Organomet. Chem. 1996, 525, 15).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.74 (d, ³J=7.5 Hz, 2H, ar), 7.49-7.48 (m, 2H, ar), 7.34-7.28 (m, 4H, ar), 3.92 (q, ³J=7.5 Hz, 1H, 91/Flu), 1.50 (d, ³J=5.5 Hz, ³J=7.5 Hz, 3H, CH₃); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 149.4, 141.0, 127.4 (2×), 124.5, 120.3, 42.9, 18.6.

9-Ethylfluorene (41)

Fluorene (5.0 g, 30.1 mmol), n-BuLi (16 ml, 40 mmol, 2.5 M in hexane), RX=iodoethane (7.04 g, 45.1 mmol). 41 was isolated as yellow oil (5.7 g, 97%). Analytical data were identical to those in the literature (K. D. Bartle, P. M. G. Bavin, D. W. Jones, R. L′Amie, Tetrahedron 1970, 26, 911).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.73 (d, ³J=10.0 Hz, 2H, ar), 7.50-7.48 (m, 2H, ar), 7.36-7.27 (m, 4H, ar), 3.94 (t, ³J=6.0 Hz, 1H, 9HFlu), 2.07 (dq, ³J=5.5 Hz, ³J=7.0 Hz, 2H, CH₂), 0.71 (t, ³J=7.5 Hz 3H, CH₃); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 147.2, 141.3, 126.8, 126.7, 124.3, 119.7, 48.5, 25.7, 9.7.

9-Isopropylfluorene (42)

Fluorene (15.0 g, 90.4 mmol), n-BuLi (48.1 ml, 120 mmol, 2.5 M in hexane), RX=2-iodopropane (14.0 ml, 139.6 mmol). 42 was isolated as a yellowish solid (18.7 g, quant.). The analytical data were identical with these to be found in the literature (M. A. Schmidt, H. G. Alt, W. Milius, J. Organomet. Chem. 1996, 525, 15).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.73 (d, ³J=7.5 Hz, 2H, ar), 7.52-7.51 (m, 2H, ar), 7.37-7.25 (m, 4H, ar), 3.91 (d, ³J=3.0 Hz, 1H, 91/Flu), 2.59-2.52 (m, 1H, CH), 0.84 (d, ³J=7.0 Hz 6H, CH₃); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 146.7, 142.1, 127.3, 127.1, 125.2, 120.0, 54.2, 32.6, 19.5 (CH₃, 2×).

9-n-Propylfluorene (43)

Fluorene (15.0 g, 90.4 mmol), n-BuLi (48.1 ml, 120 mmol, 2.5 M in hexane), RX=1-iodopropane (20.8 g, 122.3 mmol). 43 was isolated as a yellowish solid (18.6 g, quant.). The analytical data were identical to those found in the literature (A. Mathieu, Bull. Soc. Chim. Fr. 1971, 1526).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.73 (d, ³J=7.0 Hz, 2H, ar), 7.51-7.49 (m, 2H, ar), 7.36-7.27 (m, 4H, ar), 3.97 (t, ³J=6.0 Hz, 1H, 9HFlu), 1.99-1.94 (m, 2H, CH₂), 1.27-1.19 (m, 2H, CH₂), 0.86 (t, ³J=7.5 Hz 3H, CH₃); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 147.7, 141.1, 126.8, 126.7, 124.4, 119.8, 47.4, 35.4, 19.0, 14.4.

9-n-Octadecylfluorene (44)

Fluorene (7.0 g, 42.1 mmol), n-BuLi (17.35 ml, 43.4 mmol, 2.5 M in hexane), RX=1-bromooctadecane (14.53 g, 43.6 mmol). Following the usual workup 44 was isolated as a white solid (15.5 g, 88%), R_(f) 0.73 (cyclohexane).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.76-7.73 (m, 2H, ar), 7.52-7,49 (m, 2H, ar), 7.38-7.27 (m, 4H, ar), 3.96 (t, ³J=6.0 Hz, 1H, 9HFlu), 3.02-1.95 (m, 2H, CH₂), 1.31-1.14 (m, 32 H, CH₂), 0.88 (t, ³J=6.6 Hz 3H, CH₃); ¹³C{¹H} NMR (75.42 MHz, CDCl₃) δ [ppm] 147.7, 141.1, 126.8, 126.7, 124.3, 119.8, 47.5, 33.1, 31.9, 30.0, 29.7 (CH₂, 7×), 29.6 (CH₂, 3×), 29.4, 29.3, 25.7, 22.7, 14.1.

9-Benzylfluorene (45)

Fluorene (19.0 g, 114 mmol), n-BuLi (54.9 ml, 137 mmol, 2.5 M in hexane), RX=benzylchloride (17.03 ml, 148 mmol). After the usual workup 45 was isolated and recrystallized from heptane to give a white solid (25.8 g, 88.4%). The analytical data were identical to these in the literature (E. H. Licht, H. G. Alt, M. M. Karim, J. Organomet. Chem. 2000, 599, 275).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.72 (d, ³J=8 Hz, 2H, ar), 7.37-7.13 (m, 11H, ar), 3.10 (d, ³J=7.5 Hz); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 146.8, 140.8, 139.8, 129.5, 128.3, 127.1, 126.6, 126.4, 124.8, 119.8, 48.7, 40.1.

(ii) Preparation of 1-methyl-9-ethyl-fluorene (48)

(a) 1-Methylfluorene (47)

1-Methylfluoren-9-one (46) was prepared according to Mortier et al. (D. Tilly, S. S. Samanta, A.-S. Castanet, A. De, J. Mortier, Eur. J. Org. Chem. 2005, 174). 1-Methylfluoren-9-one (46) was reduced according to the general procedure of Carruthers et al. (W. Carruthers, D. Whitmarsh, J. Chem. Soc. Perkin Trans, I 1973, 1511). 1-Methylfluoren-9-one (46) (6.8 g, 35 mmol) was dissolved in 450 ml propionic acid. Red phosphorus (7.4 g) and 100 ml concentrated HI were added and the reaction mixture was refluxed for 24 h. Quantitative conversion was shown by TLC. The reaction mixture was diluted with 500 ml water, neutralized with NaOH and extracted with Et₂O (4×125 ml). The combined organic layers were washed with brine (2×125 ml), dried over MgSO₄, filtered and the volatiles removed in vacuo to afford 6.1 g (97%) 47 as a white solid. The analytical data were consistent with the literature (G. L. Grunewald, A. E. Carter, D. J. Sall, J. A. Monn, J. Med. Chem. 1988, 31, 60 and M. J. Shapiro, J. Org. Chem. 1978, 43, 3769).

¹H NMR (500 MHz, acetone-d₆) δ [ppm] 7.82 (d, ³J=8.0 Hz 1 H, ar), 7.67 (d, ³J=7.5 Hz 1H, ar), 7.58-7.56 (m, 1H, ar), 7.36-7.34 (m, 1H, ar), 7.30-7.26 (m, 2H, ar), 7.12-7.10 m, 1H, ar), 3.78 (s, 2H, 9HFlu), 2.39 (s, 3H, CH₃);

¹³C{¹H} NMR (125.77 MHz, acetone-d₅) δ [ppm] 144.4, 143.3, 143.3, 142.5, 135.5, 128.9, 128.4, 127.9, 127.9, 126.3, 121.2, 118.6, 36.6, 19.2.

(b) 1-Methyl-9-ethyl-fluorene (48)

The substitution reaction at the 9-position was performed according to the general procedure for the synthesis of 9-substituted fluorenes described above in item IV(i). 1-Methylfluorene (47) (3.01 g, 16.7 mmol) was used instead of fluorene, n-BuLi (8.06 ml, 20 mmol, 2.5 M in hexane), RX=1-iodoethane (3.39 g, 21.7 mmol). 48 was isolated to give a colorless oil (3.33 g, 95%).

¹H NMR (500 MHz, acetone-d₆) δ [ppm] 7.79-7.77 (m, 1H, ar), 7.64 (d, ³J=7.5 Hz, 1H, ar), 7.55-7.53 (m, 1H, ar), 7.34-7.24 (m, 3H, ar), 7.10-7.08 (m, 1H, ar), 4.11 (t, ³J=4.5 Hz, 1H, 91/Flu), 2.46 (s, 3H, CH₃), 2.26-2.20 (m, 2H, CH₂), 0.35 (t, ³J=7.5 Hz 3H, CH₃); C{¹H} NMR (125.75 MHz, acetone-d₆) δ [ppm] 148.0, 145.4, 142.6, 142.4, 135.2, 129.4, 128.0, 127.7, 127.6, 124.9, 120.4, 118.1, 48.5, 24.3, 19.2, 8.3.

(iii) Preparation of 1,3,8-trimethyl-9-ethyl-fluorene (55)

Reagents and conditions: a) 1,3-propanediol, ZrCl₄; n-BuLi, MeI, H₂SO₄;

b) Pd(OAc)₂, SIMES, Cs₂CO₃, 3,5-Me₂-C₆H₃B (OH)₂, dioxane; c NaClO₂, H₂O₂; d) H₂SO₄; e) H₁, P_(red), propionic acid; f) n-BuLi, EtI, THF, −60° C.

(a) 2-Bromo-6-methyl-benzaldehyde (50)

Ortho-lithiation of 1,3-dibromobenzene using the protocol of Servatovski et al. (S. Lilinski. J. Servatowski, J. Org. Chem. 2003, 68, 5384) and subsequent quenching with DMF resulted in 2,6-dibromobenzaldehyde (49) which was protected as an acetal and treated with n-BuLi, followed by quenching the lithiated intermediate with methyliodide to yield the desired deprotected 2-bromo-6-methylbenzaldehyde (50) in nearly quantitative yields:

2,6-Dibromobenzaldehyde (49) (10.0 g, 37.9 mmol) was dissolved in 160 ml dry CH₂Cl₂. Propanediol (6.4 ml, 88.5 ml), triethylorthoformate (6.83 ml, 41 mmol) and anhydrous ZrCl₄ (1.0 g) were added at ambient temperature and stirred overnight. Then NaOH (50 ml of a 10% solution) was added and stirred for an additional hour. The organic phase was separated, the aqueous phase was extracted with Et₂O (2×40 ml). The combined organic phases were washed with water (3×60 ml), dried over MgSO₄ and the volatiles were removed in vacuo to afford 12 g (98%) 2-(2,6-Dibromophenyl)-1,3-dioxane (acetal) as a slightly yellow solid.

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.55 (d, ³J=8.0 Hz 2H, ar), 7.00 (t, ³J=8.0 Hz 1H, ar), 6.19 (s, 1H, CH), 4.33-4.29 (m, 2H, CH₂), 4.02-3.97 (m, 2H, CH₂), 2.44-2.34 (m, 1 H, CH₂), 1.44-1.40 (m, 1H, CH₂); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 133.9, 132.5, 129.8, 122.9, 101.6, 66.7, 24.1. The acetal (10.1 g, 31.25 mmol) was dissolved in THF, abs. (200 ml). At −78° C. n-BuLi (15.1 ml, 2.5 M in hexane, 37.8 mmol) was added within 25 min, followed by 90 min additional stirring at that temperature. Then the reaction mixture was treated with methyliodide (5.99 g, 42.2 mmol) and stirred for 25 min at −78° C. Next the reaction mixture was allowed to warm to ambient temperature within 1.5 h. The resulting solution was quenched with HCl (290 ml of a 5 N solution) and stirred for 1.5 h at ambient temperature. The complete deprotection of the aldehyde was checked via GC analysis. Then the reaction mixture was subsequently extracted with diethylether (4×100 ml), the combined organic layers were washed with a 10% solution of sodium thiosulfate (100 ml), water (100 ml), dried over MgSO₄, filtered and the volatiles removed in vacuo. The resulting slightly yellow solid was purified via Kugelrohr distillation to afford 50 (5.97 g, 96%) as white crystals. R_(f) 0.56 (cyclohexane:ethylacetate 10:1).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 10.52 (s, 1H, CHO), 7.52-7.50 (m, 1H, ar), 7.26 (t, ³J=7.0 Hz 1H, ar), 7.22-7.20 (m, 2H, ar), 2.58 (s, 3H, CH₃); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 194.6, 142.7, 133.6, 131.8, 131.7, 131.4, 128.3, 21.2.

(b) 3,3′,5′-Trimethyl-biphenyl-carbaldehyde (51) (via Suzuki coupling)

In a 250 ml Schlenk flask dioxane, abs (60 ml), Pd(OAc)₂ (175 mg), SIMES (N,N′-bis(2,4,6-trimethylphenyl)-imidazolinium chloride, 777 mg) and Cs₂CO₃ (12.4 g) were stirred for 45 min at 80° C. until a grey solution had formed. Benzaldehyde 50 (3.1 g, 15.6 mmol) and 3,5-dimethylphenylboronic acid were added and the mixture stirred for 2 h at 80° C. (quantitative conversion, GC). The reaction mixture was allowed to cool to ambient temperature and treated with NaOH (100 ml of a 1 N solution) and diethylether (200 ml) and transferred into a separation funnel. The aqueous phase was extracted with Et₂O (2×100 ml), the combined organic layers were subsequently washed with NaOH (100 ml, 1 N), brine (100 ml), dried over MgSO₄, and the volatiles removed in vacuo. The resulting brown oil was purified by filtration over a short pad of silica gel (10×5 cm, eluent: cyclohexane/ethylacetate 20:1) to afford 51 (3.1 g, 89%) as a yellow oil. R_(f) 0.66 (cyclohexane:ethylacetate (10:1)). The product was used without any further purification.

¹H NMR (300 MHz, CDCl₃) δ [ppm] 9.96 (s, 1H, CHO), 7.44 (t, ³J=7.8 Hz 1H, ar), 7.25 (d, ³J=3.6 Hz 2H, ar), 7.04 (s, 1H, ar), 6.95, (s, 2H, ar), 2.65 (s, 3H, CH₃), 2.36 (s, 6 H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 195.0, 140.0, 139.0, 138.0, 132.7, 132.2, 131.9, 131.0, 129.7, 128.6, 128.2, 21.7, 21.4; IR (KBr): ν=3436 (br), 2920, 2858, 2765, 1689, 1677, 1600, 1584, 1463, 1191.

(c) 3,3′,5′-Trimethyl-biphenyl-carboxylic acid (52)

The aldehyde 51 (2.75 g, 11.5 mmol) was dissolved in acetonitrile (18 ml, technical grade). NaH₂PO₄ (0.453 g, dissolved in 5.5 ml H₂O) and H₂O₂ (1.93 ml of a 30% solution) was added. The reaction mixture was cooled to 0° C. (with ice/water) and NaClO₂ (2.2 g, dissolved in 19 ml water) was added within 60 min via a syringe. The solution was allowed to warm to ambient temperature and was stirred for additional 3.5 h. Then Na₂SO₃ (100 mg) was added, stirred for 5 min. After treatment with HCl (50 ml of a 10% solution) the reaction mixture was extracted with ether (3×75 ml). The combined organic phase was extracted with NaOH (4×75 ml, 1 N). The combined NaOH layers were acidified with HCl to pH 1 and extracted again with Et₂O. The combined organic layers were dried over MgSO₄ and the volatiles removed in vacuo to afford 52 (2.95 g, quant.) as a colorless oil. The product was used without any further purification.

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.36-7.18 (m, 3H, ar), 7.04 (s, 2H, ar), 6.98 (s, 1H, ar), 2.45 (s, 3H, CH₃), 2.32 (s, 6H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 180.7, 140.6, 140.4, 138.0, 135.4, 132.1, 129.8, 129.4, 129.1, 127.6, 126.3, 21.4, 20.0.

(d) 1,3,8-Trimethylfluoren-9-one (53)

In a 250 ml 1-necked round bottom flask the biphenyl-carboxylic acid 52 (3.0 g, 12.9 mmol) was treated with concentrated sulphuric acid (40 ml) at 0° C. (ice bath). The resulting dark brown solution was stirred for 15 min at 0° C., then for additional 1 h at ambient temperature. The reaction mixture was poured in ice (100 g) whereupon the color changes to a bright yellow. The suspension was neutralized with K₂CO₃ and extracted with Et₂O (3×100 ml). The combined organic phases were washed with brine (75 ml), dried over MgSO₄, filtered and the volatiles removed in vacuo to afford 53 (2.8 g, 98%) as yellow crystals. R_(f) 0.52 (cyclohexane:ethylacetate 10:1). The product was used without any further purification.

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.30-7.28 (m, 2H, ar), 7.14 (s, 1H, ar), 7.02-7.00 (m, 1H, ar), 6.82 (s, 1H, ar), 2.61 (s, 3H, CH₃), 2.57 (s, 3H, CH₃), 2.38 (s, 3H, CH₃);

¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 196.3, 144.7, 144.5, 144.2, 138.9, 138.8, 133.4, 132.2, 131.7, 131.5, 128.8, 118.6, 117.4, 21.9, 17.7, 17.6; IR (KBr): ν=3049, 3020, 2919, 1698, 1615, 1595, 1454, 1373, 1296, 1170.

(e) 1,3,8-Trimethylfluorene (54)

1,3,8-Trimethylfluoren-9-one (53) was reduced according to the general procedure of Carruthers et al. (W. Carruthers, D. Whitmarsh, J. Chem. Soc. Perkin Trans, I 1973, 1511). 1,3,8-Trimethylfluoren-9-one (53) (2.74 g, 12.3 mmol) was dissolved in propionic acid (235 ml). Red phosphorus (3.0 g) and concentrated HI (40 ml) were added and the reaction mixture was refluxed for 24 h. Quantitative conversion was shown by TLC. The reaction mixture was diluted with water (250 ml), neutralized with NaOH and extracted with Et₂O (4×125 ml). The combined organic layers were washed with brine (2×125 ml), dried over MgSO₄, filtered and the volatiles removed in vacuo to afford 2.56 g (quant.) 54 as a white solid.

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.60 (d, ³J=7.5 Hz, 1H, ar), 7.44 (s, 1H, ar), 7.28 (t, ³J=7.5 Hz, 1H, ar), 7.10 (d, ³J=7.0 Hz, 1H, ar), 6.95 (s, 1H, ar), 3.63 (s, 2H, CH₂), 2.44 (s, 3H, CHA, 2.42 (s, 3H, CHA, 2.40 (s, 3H, CH₃); ¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 141.3, 140.9, 140.8, 138.0, 135.6, 133.1, 132.8, 127.6, 126.4, 125.9, 117.1, 116.4, 33.4, 20.4, 17.9, 17.8; IR (KBr): ν=3038, 3012, 2964, 2917, 2874, 1612, 1592, 1455, 1261.

(f) 1,3,8-Trimethyl-9-ethyl-fluorene (55)

The substitution reaction at the 9-position was performed according to the general procedure for the synthesis of 9-substituted fluorenes described above in item IV(i). 1,3,8-Trimethylfluorene (54) (1.2 g, 5.77 mmol) was used instead of fluorene, n-BuLi (3.0 ml, 2.5 M in hexane, 7.5 mmol), RX=1-iodoethane (1.35 g, 8.65 mmol). 55 was isolated to give a white solid (1.36 g, quant.).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.55 (d, ³J=7.2 Hz, 1H, ar), 7.40 (s, 1H, ar), 7.27 (t, ³J=7.2 Hz, 1H, ar), 7.08 (d, ³J=7.5 Hz, 1H, ar), 6.93 (s, 1H, ar), 4.23 (t, ³J=4.2 Hz, 1H, 9HFlu), 2.49 (s, 3H, CH₃), 2.46 (s, 3H, CH₃), 2.43 (s, 3H, CH₃), 2.30 (dq, ³J=4.2 Hz, 2H, CH₂), 0.19 (t, ³J=7.8 Hz 3H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 145.3, 142.1, 136.7, 134.1, 133.7, 129.6, 128.5, 127.0, 118.0, 117.2, 46.7, 21.5, 21.1, 19.2, 19.1, 7.2.

(iv) Preparation of 9-ethyl-2,7-dibromofluorene (56)

In a 250 ml four-necked round bottom flask (wrapped with Al foil) 9-ethylfluorene (41) (5 g, 25.7 mmol) was dissolved in dry CHCl₃ (50 ml). Anhydrous FeCl₃ (0.1 g, 0.63 mmol) was added. Under an argon atmosphere bromine (8.64 g, 54.1 mmol, dissolved in 25 ml chloroform) was added dropwise at 0° C. during 20 min while stirring. After completion of the addition the reaction mixture was stirred for 3 h at ambient temperature. Then a solution of Na₂S₂O₃ (20% (w/w) in water) was added and the mixture was transferred to a separation funnel. The aqueous phase was discarded and the organic layer was washed subsequently with a solution of NaHCO₃ (saturated, 3×40 ml) and water (1×40 ml). The organic layer was dried over MgSO₄, filtered and the volatiles removed in vacuo to afford a yellow solid. Recrystallization from ethanol afforded 56 (6.3 g, 70%) as white crystals.

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.61 (s, 2H, ar), 7.56 (d, ³J=8.5 Hz, 2H, ar), 7.48 (dd, ³J=8.5 Hz, ⁴J=1.5 Hz, 2 H, ar), 3.94 (t, ³J=5.0 Hz, 1H, 9HFlu), 2.06 (dq, ³J=5.5 Hz, ³J=7.5 Hz, 2H, CH₂), 0.68 (t, ³J=7.5 Hz 3H, CH₃);

¹³C{¹H} NMR (125.77 MHz, CDCl₃) δ [ppm] 148.9, 139.4, 130.3, 127.7, 121.2, 48.4, 25.3, 9.4; HRMS Calcd. for C₁₅H₁₂Br₂: 349.9305. found 349.9286.

V. Preparation of Fluorenyl Phosphonium Salts (i) Preparation of 9-Substituted Fluorenyl-Phosphonium-Salts

General procedure for the synthesis of 9-substituted fluorenyl-phosphonium-salts:

To a solution of a 9-substituted fluorene (31 mmol) in Et₂O, abs, (100 ml) n-BuLi (29 mmol, 2.5 M solution in hexane) was added at −60° C. The solution immediately turned red and was stirred for 10 min at −60° C., then for additional 2 h at ambient temperature. After cooling to −60° C. again, a dialkylphosphinous chloride R₂PCl (22 mmol) was added. The reaction mixture was stirred for 10 min at −60° C., then overnight at rt. After removing the LiCl by filtration over a short pad of Celite®, the resulting clear filtrate was quenched with HBF₄ (31.5 mmol of a diethylether complex). After separation via suction filtration the crude product was dissolved in 20 ml of CHCl₃ and added dropwise into Et₂O (1 l, vigorously stirred). Filtration and removal of the volatiles in vacuo afforded the pure product as a white solid.

The following 9-substituted fluorenyl-phosphonium-salts were prepared according to the above general procedure:

9-MeFluPCy₂.HBF₄ (8a)

Fluorene derivative=9-methylfluorene (40) (1.0 g, 5.55 mmol), n-BuLi (2.7 ml of a 2.0 M in hexane, 5.4 mmol), R₂PCl=Cy₂PCl (0.95 g, 4.08 mmol), HBF₄.Et₂O (1.4 ml, 5.55 mmol). 8a was isolated to give a white solid (1.35 g, 71%).

¹H NMR (300 MHz, CD₃CN) δ [ppm] 8.02-7.99 (m, 2H, ar), 7.81-7.78 (m, 2H, ar), 7.66-7.61 (m, 2H, ar), 7.56-7.50 (m, 2 H, ar), 6.00 (d, ¹J=464 Hz 1H, PH), 2.44-2.30 (m, 4H, CH₂), 2.03 (d, ³J=16.8 Hz, 3H, CH₃), 1.96-1.92 (m, 2H, CH), 1.75-1.49 (m, 8H, CH₂), 1.31-1.04 (m, 8H, CH₂); ¹³C{¹H} NMR (75.4 MHz, CD₃CN) δ [ppm] 140.9 (d, ^(PC)J=3.1 Hz), 140.1 (d, ^(PC)J=4.3 Hz), 130.0 (d, ^(PC)J=2.0 Hz), 128.6 (d, ^(PC)J=2.0 Hz), 124.6 (d, ^(PC)J=3.3 Hz), 121.3, 47.6 (d, ^(PC)J=33.9 Hz), 30.4 (d, ^(PC)J=35 Hz), 28.5 (d, ^(PC)J=3.9 Hz), 27.5 (d, ^(PC)J=3.8 Hz), 25.8 (d, ^(PC)J=13 Hz), 25.6 (d, ^(PC)J=13 Hz), 24.4, 21.6; ³¹P{¹H} NMR (121.4 MHz, CD₃CN) δ [ppm] 38.8; ³¹P NMR (121.4 MHz, CD₃CN) δ [ppm] 38.8 (d, ^(PH)J=463 Hz).

9-MeFluPiPr₂.HBF₄ (5a)

Fluorene derivative=9-methylfluorene (40) (1.5 g, 8.31 mmol), nBuLi (4.05 ml, 2.0 M in hexane, 8.1 mmol), R₂PCl=iPr₂PCl (0.9 ml, 5.67 mmol), HBF₄.Et₂O (2.4 ml, 9.51 mmol). 5a was isolated to give a white solid (1.37 g, 63%).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.94-7.86 (m, 4H, ar), 7.60-7.49 (m, 4H, ar), 7.27 (d, ¹J=483 Hz 1H, PH), 2.65-2.50 (m, 2H, CH), 2.15 (d, ³J(PH)=16.8 Hz, 3H, CH₃), 1.33 (dd, ³J=7.2 Hz, ³J(PH)=18.3 Hz, 6H, CH₃), 1.06 (dd, ³J=7.5 Hz, ³J(PH)=17.7 Hz, 6H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 142.2 (d, ^(PC)J=2.2 Hz), 140.2 (d, ^(PC)J=4.3 Hz), 130.3, 129.2 (d, ^(PC)J=1.7 Hz), 125.2 (d, ^(PC)J=3.7 Hz), 121.2, 47.9 (d, ^(PC)J=34 Hz), 22.7, 21.2 (d, ^(PC)J=36.3 Hz), 19.3 (d, ^(PC)J=2.9 Hz), 17.8 (d, ^(PC)J=3.0 Hz); ¹¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 39.4; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 39.4 (d, ^(PH)J=482 Hz).

9-EtFluPCy₂.HBF₄ (9a)

Fluorene derivative=9-ethylfluorene (41) (1.65 g, 8.55 mmol), n-BuLi (3.3 ml, 2.5 M in hexane, 8.25 mmol), R₂PCl=Cy₂PCl (1.26 g, 5.43 mmol), HBF₄.Et₂O (2.2 ml, 8.7 mmol). 9a was isolated to give a white solid (1.97 g, 76%).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.90-7.87 (m, 2H, ar), 7.79 (d, ³J=7.9 Hz, 2H, ar), 7.61-7.49 (m, 4H, ar), 6.54 (d, ¹J=480 Hz 1H, PH), 2.80-2.71 (m, 2H, CH₂ (ethyl)), 2.30-2.18 (m, 2H, CH), 1.91-1.08 (m, 19H, CH₂), 0.32 (t, ³J=6.9 Hz, 3H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 141.6 (d, ^(PC)J=4.5 Hz), 139.7 (d, ^(PC)J=3.0 Hz), 130.2, 129.1, 125.1 (d, ^(PC)J=3.0 Hz), 121.1, 52.9 (d, ^(PC)J=33 Hz), 31.2 (d, ^(PC)J=35 Hz), 29.4 (d, ^(PC)J=2.6 Hz), 28.0 (d, ^(PC)J=4 Hz), 27.4, 26.7 (d, ^(PC)J=13 Hz), 26.5 (d, ^(PC)J=13 Hz), 24.9, 6.7 (d, ^(PC)J=11 Hz); ³¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 34.4; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 34.4 (d, ^(PC)J=480 Hz).

9-EtFluPiPr₂.HBF₄ (6a)

Fluorene derivative=9-Ethylfluorene (41) (0.54 g, 2.78 mmol), n-BuLi (1.35 ml, 2.0 M in hexane, 2.7 mmol), R₂PCl=iPr₂PCl (0.269 g, 1.76 mmol), HBF₄.Et₂O (0.55 ml, 2.7 mmol). 6a was isolated to give a white solid (0.69 g, 99%).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.90-7.82 (m, 4H, ar), 7.61-7.50 (m, 4H, ar), 6.70 (d, ¹J=480 Hz 1H, PH), 2.79-2.72 (m, 2H, CH₂ (ethyl)), 2.64-2.54 (m, 2H, CH), 1.30 (dd, ³J=7.2 Hz, ³J(PH)=18.3 Hz, 6H, CH₃), 1.05 (dd, ³J=7.2 Hz, ³J(PH)=17.4 Hz, 6H, CHO, 0.33 (t, ³J=6.9 Hz, 3H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 141.6 (d, ^(PC)J=4.8 Hz), 139.5 (d, ^(PC)J=3.0 Hz), 130.3 (d ^(PC)J=2.1 Hz), 129.2 (d, ^(PC)J=3.4 Hz), 125.1 (d, ^(PC)J=3.4 Hz), 121.3, 52.7 (d, ^(PC)J=34 Hz), 27.6, 21.3 (d, ^(PC)J=36.7 Hz), 19.5 (d, ^(PC)J=2.4 Hz), 17.8 (d, ^(PC)J=3.5 Hz), 6.6 (d, ^(PC)J=11 Hz);

³¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 40.8; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 40.8 (d, ^(PH)J=478 Hz).

9-iPrFluPCy₂.HBF₄ (22a)

Fluorene derivative=9-i-propylfluorene(42) (1.15 g, 5.54 mmol), n-BuLi (2.7 ml, 2.0 M in hexane, 5.4 mmol), R₂PCl=Cy₂PCl (0.9 ml, 4.08 mmol), HBF₄.Et₂O (1.2 ml, 4.76 mmol). 22a was isolated to give a white solid (1.30 g, 64%).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.89 (d, ³J=6.9 Hz, 2H, ar), 7.79 (d, ³J=7.5 Hz, 2H, ar), 7.62-7.50 (m, 4H, ar), 6.79 (d, ¹J=479 Hz 1H, PH), 3.01 (dq, ³J=6.6 Hz, ³J=4.8 Hz, 1H, CHCH₃), 2.21-2.09 (m, 2H, CH), 1.97-1.86 (m, 2 H, CH₂), 1.81-1.59 (m, 6H, CH₂), 1.51-1.37 (m, 4H, CH₂), 1.23-1.07 (m, 8H, CH₂), 0.93 (d, ³J=6.6 Hz, 6H, CH₃);

¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 141.5 (d, ^(PC)J=5.1 Hz), 139.6 (d, ^(PC)J=2.6 Hz), 130.3, 129.0, 125.7 (d ^(PC)J=2.9 Hz), 121.1, 56.4 (d, ^(PC)J=33 Hz), 34.4, (d, ^(PC)J=35.6 Hz), 29.3 (d, ^(PC)J=3.8 Hz), 28.1 (d, ^(PC)J=3.7 Hz), 26.9 (d, ^(PC)J=12.9 Hz), 26.6 (d, ^(PC)J=12.5 Hz), 24.9, 17.8 (d, ^(PC)J=6.6 Hz); ³¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 25.0; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 25.0 (d, ^(PH)J=477 Hz).

9-iPrFluPiPr₂.HBF₄ (23a)

Fluorene derivative=9-i-propylfluorene (42) (1.16 g, 5.57 mmol), n-BuLi (2.7 ml, 2.0 M in hexane, 5.4 mmol), R₂PCl=iPr₂PCl (0.66 g, 4.1 mmol), HBF₄.Et₂O (1.2 ml, 4.76 mmol). 23a was isolated to give a white solid (1.20 g, 71%).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.90-7.82 (m, 4H, ar), 7.62-7.50 (m, 4H, ar), 6.99 (d, ¹J=477 Hz 1H, PH), 3.09-2.99 (m, 1H, CH), 2.59-2.44 (m, 2H, CH), 1.32 (dd, ³J=7.5 Hz, ³J(PH)=18.9 Hz, 6H, CH₃), 1.03 (dd, ³J=7.5 Hz, ³J(PH)=17.7 Hz, 6H, CH₃), 0.94 (d, ³J=6.9 Hz, 6H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 141.5 (d, ^(PC)J=5.1 Hz), 139.4 (d, J=2.4 Hz), 130.3 (d ^(PC)J=1.6 Hz), 129.1 (d, ^(PC)J=1.3 Hz), 125.7 (d, ^(PC)J=3.6 Hz), 121.2, 56.1 (d, ^(PC)J=33.2 Hz), 34.4, 21.1 (d, ^(PC)J=38.5 Hz), 19.5 (d, ^(PC)J=2.2 Hz), 17.8 (d, ^(PC)J=2.6 Hz), 6.6 (d, ^(PC)J=6.5 Hz); ³¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 31.3; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 31.3 (d, ^(PH)J=473 Hz).

9-n-PrFluPCy₂.HBF₄ (24a)

Fluorene derivative=9-n-propylfluorene (43) (3.0 g, 14.4 mmol), n-BuLi (5.6 ml, 2.5 M in hexane, 14.0 mmol), R₂PCl=Cy₂PCl (2.37 g, 10.2 mmol), HBF₄.Et₂O (2.0 ml, 14 mmol). 24a was isolated to give a white solid (4.13 g, 73%).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.87 (d, ³J=7.5 Hz, 2H, ar), 7.79 (d, ³J=7.5 Hz, 2H, ar), 7.59-7.50 (m, 4H, ar), 6.54 (d, ¹J=480.5 Hz 1H, PH), 2.67-2.63 (m, 2H, CH₂ (propyl)), 2.24-2.21 (m, 2H, CH), 1.91-1.10 (m, 19H, CH₂), 0.73 (t, ³J=7.5 Hz, 3H, CH₉), 0.66-0.58 (m, 2H, CH₂ (propyl)); ¹³C{¹H} NMR (125.75 MHz, CDCl₃) δ [ppm] 141.4 (d, ^(PC)J=4.5 Hz), 140.2 (d, ^(PC)J=3.8 Hz), 130.2, 129.1, 125.1 (d, ^(PC)J=2.8 Hz), 121.1, 52.4 (d, ^(PC)J=33 Hz), 40.0, 31.3 (d, ^(PC)J=34.6 Hz), 29.4 (d, ^(PC)J=3.6 Hz), 28.1 (d, ^(PC)J=3.3 Hz), 26.8 (d, ^(PC)J=13.8 Hz), 26.5 (d, ^(PC)J=12.4 Hz), 24.9, 16.0 (d, ^(PC)J=10.4 Hz), 13.6; ³¹P{¹H} NMR (202.45 MHz, CDCl₃) δ [ppm] 34.9; ³¹P NMR (202.45 MHz, CDCl₃) δ [ppm] 34.9 (d, ^(PH)J=483 Hz).

9-C₁₈H₃₇FluPCy₂.HBF₄ (11a)

Fluorene derivative=9-octadecylfluorene (44) (2.48 g, 5.9 mmol), n-BuLi (2.1 ml, 2.5 M in hexane, 5.25 mmol), R₂PCl=Cy₂PCl (0.92 g, 3.94 mmol), HBF₄.Et₂O (1.8 ml). In the absence of precipitation water (80 ml, treated with aqueous HBF₄ (8 N)) was added, whereupon a white solid precipitated. The solid was removed via suction filtration to afford 11a as a white solid (2.6 g, 94%).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.87 (d, ³J=7.2 Hz, 2H, ar), 7.79-7.77 (m, 2H, ar), 7.60-7.50 (m, 4H, ar), 6.59 (d, ¹J=483 Hz 1H, PH), 2.71-2.59 (m, 2H, CH₂), 2.27-2.13 (m, 2H, CH), 1.92-1.02 (m, 50H, CH₂), 0.87 (t, ³J=6.6 Hz, 3H, CH₃), 0.60-0.49 (m, 2H, CH₂); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 141.4 (d, ^(PC)J=4.2 Hz), 140.2, 130.2, 129.1, 125.1, 121.0, 52.4 (d, ^(PC)J=32.2 Hz), 34.0, 31.9, 31.3 (d, ^(PC)J=34.5 Hz), 29.7-29.1 (CH₂, 14×), 28.1 (d, ^(PC)J=3.2 Hz), 26.8 (d, ^(PC)J=13.2 Hz), 26.6 (d, ^(PC)J=12.6 Hz), 24.9, 22.7, 22.4 (d, ^(PC)J=9.9 Hz), 14.1; ³¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 34.1; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 34.1 (d, ^(PH)J=482 Hz).

9-C₁₈H₃₇FluPiPr₂.HBF₄ (7a)

Fluorene derivative=9-octadecylfluorene (44) (2.38 g, 5.7 mmol), n-BuLi (2.0 ml, 2.5 M in hexane, 5.0 mmol), R₂PCl=iPr₂PCl (0.575 g, 3.77 mmol), HBF₄.Et₂O (2.0 ml, 9.8 mmol). In the absence of precipitation, the volatiles were evaporated in vacuo to give a colorless solid, which was dissolved in diethylether (50 ml) and treated with HBF₄.Et₂O (1 ml). Aqueous HBF₄ (50 ml, 4 N) was added, the mixture was stirred vigorously, the aqueous phase separated and kept in an open beaker overnight. The crystals which had formed were separated via suction filtration and dried in vacuo to afford 7a (1.90 g, 81%) as white crystals.

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.88 (d, ³J=6.9 Hz, 2H, ar), 7.81 (d, ³J=6.9 Hz, 2H, ar), 7.59-7.53 (m, 4H, ar), 6.65 (d, ¹J=481 Hz 1H, PH), 2.71-2.61 (m, 2H, CH₂), 2.61-2.49 (m, 2H, CH), 1.31 (dd, ³J=7.2 Hz, ³J(PH)=12.3 Hz, 6H, CH₃), 1.27-1.11 (m, 30H, CH₂), 1.05 (dd, ³J=7.5 Hz, ³J(PH)=17.4 Hz, 6H, CH₃), 0.88 (t, ³J=6.9 Hz, 3H, CH₃), 0.61-0.50 (m, 2H, CH₂); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 141.4 (d, ^(PC)J=5.1 Hz), 139.9 (d, ^(PC)J=2.9 Hz), 130.3, 129.2, 125.0 (d, ^(PC)J=2.9 Hz), 121.3, 52.3 (d, ^(PC)J=33.5 Hz), 34.1, 31.9, 29.6 (CH₂, 11x), 29.5, 29.4, 29.3, 29.1, 22.7, 22.2 (d, ^(PC)J=10.5 Hz), 21.3 (d, ^(PC)J=37 Hz), 19.5 (d, ^(PC)J=1.8 Hz), 17.8 (d, ^(PC)J=2.5 Hz), 14.1; ³¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 40.8; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 40.8 (d, ^(PC)J=480 Hz).

9-BnFluPCy₂.HBF₄ (10a)

Fluorene derivative=9-benzylfluorene (45) (6.0 g, 23.2 mmol), n-BuLi (8.6 ml, 2.5 M in hexane, 21.5 mmol), R₂PCl=Cy₂PCl (3.85 g, 16.5 mmol), HBF₄.Et₂O (3.22 ml, 23.6 mmol). 10a was isolated to give a white solid (5.43 g, 61%).

¹H NMR (500 MHz, acetone-d₆) δ [ppm] 8.32-8.30 (m, 2H, ar), 7.88-7.86 (m, 2H, ar), 7.60-7.57 (m, 4H, ar), 6.90-6.87 (m, 1H, ar), 6.82-6.79 (m, 2H, ar), 6.70 (d, ¹J=472.5 Hz, 1H, PH), 6.69-6.67 (m, 2H, ar), 4.25 (d, ³J=7 Hz, 2 H, CH₂), 2.88-2.79 (m, 2H, CH), 1.96-1.94 (m, 2H, CH₂), 1.77-1.08 (m, 18H, CH₂); ¹³C{¹H} NMR (125.77 MHz, acetone-d₆) δ [ppm] 142.7 (d, ^(PC)J=4.5 Hz), 140.5 (d, ^(PC)J=3.5 Hz), 133.8, 133.7, 131.1, 129.3, 128.1, 127.7, 127.3 (d, ^(PC)J=3.9 Hz), 122.1, 53.8 (d, ^(PC)J=32.2 Hz), 39.5, 32.0 (d, ^(PC)J=34.5 Hz), 30.0 (d, ^(PC)J=3.5), 29.0 (d, ^(PC)J=3.0), 27.2 (d, ^(PC)J=12.0), 27.0 (d, ^(PC)J=13.3), 25.6; ³¹P{¹H} NMR (202.46 MHz, acetone-d₆) δ [ppm] 35.7; ³¹P NMR (202.46 MHz, acetone-d₆) δ [ppm] 35.7 (d, ^(PH)J=472.6 Hz).

9-BnFluPiPr₂.HBF₄ (26a)

Fluorene derivative=9-benzylfluorene (45) (8.1 g, 31.3 mmol), n-BuLi (11.6 ml, 2.5 M in hexane, 29 mmol), R₂PCl=iPr₂PCl (3.32 g, 22.3 mmol), HBF₄.Et₂O (4.35 ml, 31.9 mmol). After separation via suction filtration, the crude product was dissolved in acetonitrile (20 ml), added dropwise into Et₂O (11, vigorous stirring). Filtration and removal of the volatiles in vacuo afforded the pure product 26a as white solid (9.8 g, 95%).

¹H NMR (500 MHz, CD₃CN) δ [ppm] 8.04-8.02 (m, 2H, ar), 7.79-7.77 (m, 2H, ar), 7.56-7.54 (m, 4H, ar), 6.92-6.90 (m, 1 H, ar), 6.84-6.81 (m, 2H, ar), 6.61-6.60 (m, 2H, ar), 6.35 (d, ¹J=470 Hz, 1H, PH), 4.00 (d, ³J=6.00 Hz, 2H, CH₂), 2.83-2.75 (m, 2H, CH), 1.18 (dd, ³J=7.5 Hz′ ³J(PH)=18.5 Hz, 6H, CHA 1.00 (dd, ³J=7.0 Hz, ³J(PH)=17.5 Hz, 6H, CH₃); ¹³C{¹H} NMR (125.8 MHz, CD₃CN) δ [ppm] 141.2 (d, ^(PC)J=4.8 Hz), 138.7, 132.2 (d, ^(PC)J=14.3 Hz), 130.0, 129.9, 128.2, 127.1, 126.7, 125.8 (d, ^(PC)J=31.8 Hz), 38.5, 21.0 (d, ^(PC)J=36.2 Hz), 18.3 (d, ^(PC)J=2.3 Hz), 17.0 (d, ^(PC)J=1.4 Hz); ³¹P{¹H} NMR (202.5 MHz, CD₃CN) δ [ppm] 43.8; ³¹P NMR (202.5 MHz, CD₃CN) δ [ppm] 43.8 (d, ^(PH)J=465.2 Hz).

9-Et-1-MeFluPCy₂.HBF₄ (12a)

Fluorene derivative=9-ethyl-1-methylfluorene (48) (2.0 g, 9.56 mmol), n-BuLi (3.67 ml, 2.5 M in hexane, 9.18 mmol), R₂PCl=Cy₂PCl (1.78 g, 7.65 mmol), HBF₄.Et₂O (1.25 ml, 9.18 mmol). 12a was isolated to give a white solid (3.5 g, 93%).

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.86 (d, ³J=7.5 Hz, 1H, ar), 7.74 (d, ³J=7.5 Hz, 1H, ar), 7.68 (d, ³J=7.5 Hz, 1H, ar), 7.59 (t, ³J=7.5 Hz, 1H, ar), 7.54-7.47 (m, 2H, ar), 7.24 (d, ³J=7.5 Hz, 1H, ar), 6.50 (dd, ¹J=465.5 Hz, ³J=4.0 Hz, 1H, PH), 3.06-2.97 (m, 1H, CH₂ (ethyl)), 2.79-2.68 (m, 2H, CH₂(ethyl)+CH(Cy)), 2.66 (s, 3H, CH₃), 2.35-2.32 (m, 1H, CH(Cy)), 2.02-1.65 (m, 7H, CH₂), 1.56-1.34 (m, 7H, CH₂), 1.13-1.08 (m, 1H, CH₂), 0.91-0.87 (m, 4H, CH₂), 0.68-0.59 (m, 1H, CH₂), 0.39 (t, ³J=7.0 Hz, 3H, CH₃); ¹³C{¹H} NMR (125.75 MHz, CDCl₃) δ [ppm] 142.6 (d, ^(PC)J=4.0 Hz), 142.3 (d, ^(PC)J=4.5 Hz), 139.8 (d, ^(PC)J=4.5 Hz), 137.4 (d, ^(PC)J=3.3 Hz), 136.8 (d, ^(PC)J=2.8 Hz), 132.2, 131.0, 130.8, 129.2 (d, ^(PC)J=2.3 Hz), 124.6 (d, ^(PC)J=4.1 Hz), 121.4, 119.1, 54.7 (d, ^(PC)J=31.3 Hz), 32.1 (d, ^(PC)J=37.3 Hz), 31.8 (d, ^(PC)J=33.3 Hz), 30.6 (d, ^(PC)J=3.8 Hz), 28.7 (d, ^(PC)J=3.6 Hz), 28.5 (d, ^(PC)J=3.4 Hz), 27.2, 27.2, 27.2, 27.1, 27.1, 27.0, 26.9, 26.8, (d, ^(PC)J=13.2 Hz), 27.1 (d, ^(PC)J=13.2 Hz), 25.2, 20.1, 7.4 (d, ^(PC)J=11 Hz); ³¹P{¹H} NMR (202.5 MHz, CDCl₃) δ [ppm] 27.5; ³¹P NMR (202.5 MHz, CDCl₃) δ [ppm] 27.5 (d, ^(PH)J=471 Hz).

9-Et-1,3,8-Me₃-FluPCy₂.HBF₄ (29a)

Fluorene derivative=1,3,8-trimethyl-9-ethyl-fluorene (55) (0.8 g, 3.4 mmol), n-BuLi (1.29 ml, 2.5 M in hexane), R₂PCl=Cy₂PCl (0.633 g, 2.72 mmol), HBF₄-Et₂O (0.8 ml, 3.2 mmol). 29a was isolated to give a white solid (1.29 g, 92%).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 7.89 (d, ³J=7.5 Hz, 1H, ar), 7.52 (s, 1H, ar), 7.49-7.43 (m, 1H, ar), 7.22 (d, ³J=7.5 Hz, 1H, ar), 7.05 (s, 1H, ar), 6.30 (dt, ¹J=469 Hz, ³J=4.5 Hz, 1H, PH), 2.96 (dg, ³J(PH)=5.7 Hz, ³J=7.2 Hz, 2H, CH₂ (ethyl)), 2.66 (s, 3H, CH₃), 2.62 (s, 3H, CH₃), 2.44 (s, 3H, CH₃), 2.24-2.19 (m, 2H, CH), 2.12-1.04 (m, 20H, CH₂), 0.44 (t, ³J=7.2 Hz, 3H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 142.6 (d, ^(PC)J=4.8 Hz), 142.5 (d, ^(PC)J=4.5 Hz), 140.8, 137.0 (d, ^(PC)J=4.4 Hz), 135.4 (d, ^(PC)J=3.2 Hz), 135.0 (d, ^(PC)J=3.2 Hz), 133.8 (d, ^(PC)J=4.1 Hz), 133.3 (d, ^(PC)J=2.3 Hz), 132.1 (d, ^(PC)J=2.3 Hz), 130.5 (d, ^(PC)J=2.4 Hz), 119.3, 118.6, 56.8 (d, ^(PC)J=28.9 Hz), 32.9 (d, ^(PC)J=17.3 Hz), 32.5 (d, ^(PC)J=17.7 Hz), 29.4 (d, ^(PC)J=3.3 Hz), 27.6 (d, ^(PC)J=4.8 Hz), 27.5 (d, ^(PC)J=4.8 Hz), 26.9 (d, ^(PC)J=13.5 Hz), 26.7 (d, ^(PC)J=13.1 Hz), 24.8, 23.7, 21.3, 20.3, 20.1, 7.1 (d, ^(PC)J=11 Hz); ³¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 27.7; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 27.7 (d, ^(PH)J=469 Hz).

9-PhFluPiPr₂.HBF₄ (30a)

Fluorene derivative=9-phenylfluorene (prepared according to a standard literature method, e.g. F. Ullman, R. von Wurstemberger, Chem. Ber. 1904, 37, 73-78) (0.72 g, 2.97 mmol), n-BuLi (1.08 ml, 2.5 M solution in hexane), R₂PCl=iPr₂PCl (0.33 ml, 2.03 mmol), HBF₄.Et₂O (0.6 ml, 2.37 mmol). 30a was isolated to give a white solid (0.84 g, 93%).

¹H NMR (300 MHz, CDCl₃) δ [ppm] 9.49 (d, ¹J=490 Hz 1H, PH), 7.98-7.91 (m, 4H, ar), 7.85 (d, J=8.1 Hz, 2H, ar), 7.64-7.52 (m, 4H, ar), 7.45 (t, ³J=7.2 Hz, 2H, ar), 7.37-7.32 (m, 1H, ar), 2.30-2.21 (m, 2H, CH), 1.14 (dd, ³J=7.2 Hz, ³J(PH)=18.0 Hz, 6H, CH₃), 1.02 (dd, ³J=7.5 Hz, ³J(PH)=17.7 Hz, 6H, CH₃); ¹³C{¹H} NMR (75.4 MHz, CDCl₃) δ [ppm] 140.6 (d, ^(PC)J=4.5 Hz), 140.3 (d, ^(PC)J=2.9 Hz), 135.2, 130.5, 130.0, 129.4, 129.1, 127.3 (d, ^(PC)J=5.9 Hz), 126.7 (d, ^(PC)J=3.1 Hz), 121.5, 56.5 (d, ^(PC)J=33.8 Hz), 21.0 (d, ^(PC)J=37.3 Hz), 19.6 (d, ^(PC)J=2.4 Hz), 17.7 (d, ^(PC)J=2.5 Hz); ³¹P{¹H} NMR (121.4 MHz, CDCl₃) δ [ppm] 30.6; ³¹P NMR (121.4 MHz, CDCl₃) δ [ppm] 30.6 (d, ^(PH)J=489 Hz).

(ii) Preparation of HFluPtBu₂.HBF₄ (25a)

Fluorene (0.505 g, 3.04 mmol) dissolved in THF, abs (10 ml) was treated with n-BuLi (1.5 ml, 2.0 M in hexane) at −80° C. The mixture turned orange and was stirred for additional 4 h at ambient temperature. Then tBu₂PCl (0.476 g, 2.6 mmol) was added at −80° C., as well as 10 ml heptane, abs. The reaction mixture was refluxed overnight, filtered under Schlenk conditions over a short pad of Celite® and the clear filtrate quenched with HBF₄-Et₂O (0.7 ml, 2.8 mmol) to afford a white residue, which could be crystallized from ethylacetate. After separation of the solids via suction filtration the crude product was dissolved in 3 ml of CHCl₃ and added dropwise into Et₂O (200 ml, vigorously stirred). Filtration and removal of the volatiles in vacuo afforded pure 25a (0.54 g, 52%) as a white solid.

¹H NMR (300 MHz, CD₃CN) δ [ppm] 8.05-7.98 (m, 2H, ar), 7.86-7.77 (m, 2H, ar), 7.63-7.54 (m, 4H, ar), 6.27 (d, ¹J=463 Hz 1H, PH), 5.37 (d, ²J(PH)=15.6 Hz, 1H, CH), 1.85 (d, ³J(PH)=17.1 Hz, 9H, CH₃), 0.91 (d, ³J(PH)=17.1 Hz, 9H. CH₃); ¹³C{¹H} NMR (75.4 MHz, CD₃CN) δ [ppm] 139.0, 135.1, 129.4 (d, ^(PC)J=10 Hz), 128.1 (d, ^(PC)J=32 Hz), 125.7 (d, ^(PC)J=87 Hz), 121.2 (d, ^(PC)J=28.0 Hz), 38.4 (d, ^(PC)J=34 Hz), 36.5 (d, ^(PC)J=23.7 Hz), 34.5 (d, ^(PC)J=30.0 Hz), 27.5, 26.6; ³¹P{¹H} NMR (121.4 MHz, CD₃CN) δ [ppm] 52.1; ³¹P NMR (121.4 MHz, CD₃CN) δ [ppm] 52.1 (d, ^(PH)J=462 Hz).

(iii) Preparation of 9-Et-2,7-Br₂FluPiPr₂.HBF₄ (31a)

In a 100 ml Schlenk flask diisopropylamine (1.03 ml, 7.4 mmol) was dissolved in THF (20 ml), abs. At −60° C. n-BuLi (2.7 ml of a 2.0 molar solution in hexane, 6.8 mmol) was added. The solution was stirred at −60° C. for 10 min, then for additional 30 min at 0° C. The formed LDA-solution was added to a solution of 9-ethyl-2,7-dibromofluorene (56) (2.5 g, 7.08 mmol) in Et₂O (40 ml) at −60° C. The red reaction mixture was stirred for 30 min at −60° C., then for 1.5 h at ambient temperature (at lower temperatures a thick reddish precipitate is formed). Then iPr₂PCl (0.9 ml, 5.66 mmol) was added at −60° C. The reaction mixture was stirred at ambient temperature for 2 h (color changes from red to yellow) and filtered over a small pad of Celite®. The clear, slightly yellow filtrate was quenched with HBF₄.Et₂O (1.80 ml, 13.2 mmol) which led to precipitation of the phosphonium salt as a white solid. The solid was separated via suction filtration, slurried in H₂O (15 ml, to remove residual ammonium salt) and filtered again. The collected white solid was dissolved in 10 ml chloroform and 1 ml acetonitrile, and the solution added dropwise to vigorously stirred Et₂₀ (400 ml) to obtain a colourless precipitate. Filtration and removal of the volatiles in vacuo afforded 31a as white solid (2.82 g, 90%).

¹H NMR (500 MHz, CD₃CN) δ [ppm] 7.98 (t, ⁴J=1.5 Hz, 2H, ar), 7.91 (d, ³J=8.0 Hz, 2H, ar), 7.81 (dt, ³J=8.0 Hz, ⁴J=1.5 Hz 2H, ar), 6.24 (d, ¹J=470 Hz 1H, PH), 2.80-2.71 (m, 2H, CH), 2.70-2.64 (m, 2H, CH₂), 1.17 (dd, ³J=7.5 Hz, ³J(PH)=19 Hz, 6H, CH₃), 1.01 (dd, ³J=7.0 Hz, ³J(PH)=18 Hz, 6H, CH₃), 0.30 (t, ³J=7.0 Hz, 3H, CH₃);

¹³C{¹H} NMR (125.75 MHz, CD₃CN) δ [ppm] 141.3 (d, ^(PC)J=2.1 Hz), 139.7 (d, ^(PC)J=4.5 Hz), 133.4, 127.9 (d, ^(PC)J=3.8 Hz), 123.1, 122.2 (d, ^(PC)J=2.0 Hz), 52.5 (d, ^(PC)J=33.9 Hz). 26.9, 20.9 (d, ^(PC)J=35.1 Hz), 18.3 (d, ^(PC)J=2.0 Hz), 16.9 (d, ^(PC)J=1.4 Hz), 18.1 (d, ^(PC)J=3.4 Hz), 5.4 (d, ^(PC)J=10.1 Hz); ³¹P{¹H} NMR (202.45 MHz, CD₃CN) δ [ppm] 42.1; ³¹P NMR (202.45 MHz, CD₃CN) δ [ppm] 34.9 (d, ^(PH)J=470.1 Hz).

(iv) Preparation of BnFluP(nButBu).HBF₄ (27a) and EtFluP (nButBu).HBF₄ (28a) BnFluP(nButBu).HBF₄ (27a)

To a solution of 9-benzylfluorene (45) (9.24 g, 35.7 mmol) in THF, abs, (75 ml) n-BuLi (13.8 ml, 2.5 M in hexane, 34.7 mmol) was added at −60° C. The solution immediately turned red. After stirring for 1 h at ambient temperature, the reaction mixture was added to a solution of tBuPCl₂ (5.2 g 32.7 mmol, dissolved in 50 ml Et₂O, abs) at −80° C. At the end of the addition, the red color remained. After stirring over night at ambient temperature, n-BuLi (16.8 ml, 2.5 M in hexane, 41.9 mmol) was added at −60° C. The reaction mixture was stirred for 10 min at −60° C., then for 2 h at ambient temperature. The suspension was filtered over a small pad of Celite® and the clear reddish filtrate was quenched with HBF₄.Et₂₀ (4.0 ml, 29.3 mmol) to precipitate the phosphonium salt. After separation via suction filtration the crude product was dissolved in acetonitrile (20 ml) and the solution added dropwise to vigorously stirred Et₂O (1 l) to obtain a colorless precipitate. Filtration and removal of the volatiles in vacuo afforded 27a as white solid (2.65 g, 17%).

¹H NMR (500 MHz, CD₃CN) δ [ppm] 8.19-8.18 (m, 1H, ar), 8.10-8.08 (m, 1H, ar.), 7.78-7.77 (m, 1H, ar), 7.73-7.71 (m, 1 H, ar), 7.56-7.50 (m, 4H, ar), 6.93-6.89 (m, 1H, ar), 6.82-6.79 (m, 2H, ar), 6.62-6.60 (m, 2H, ar), 4.09-4.00 (m, 2H, CH₂, bn), 2.81-2.77 (m, 1H, CH₂, n-Bu), 2.42-2.38 (m, 1H, CH₂, n-Bu), 1.95-1.94 (m, 2H, CH₂, n-Bu), 1.66-1.59 (m, 2H, CH₂, n-Bu), 1.01 (t, ³J=7.6 Hz, 3H, CH₃, n-Bu), 0.74 (d, ³J=17.5 Hz, 9H, CH₃, t-Bu); ¹³C{¹H} NMR (125.77 MHz, CD₃CN) δ [ppm] 141.2 (d, ^(PC)J=4.5 Hz), 141.0 (d, ^(PC)J=4.4 Hz), 139.5 (d, ^(PC)J=2.5 Hz), 138.4 (d, ^(PC)J=1.9 Hz), 132.0 (d, ^(PC)J=13.8), 132.1, 131.9, 130.0, 130.0, 129.8, 128.0 (d, ^(PC)J=6.5 Hz), 127.0, 126.7, 126.4 (d, ^(PC)J=3.4 Hz), 125.7 (d, ^(PC)J=2.8 Hz), 121.1, 120.9, 52.1 (d, ^(PC)J=32.8 Hz), 38.9, 33.5 (d, ^(PC)J=34.0 Hz), 29.1 (d, ^(PC)J=7.5 Hz), 25.2, 23.2 (d, ^(PC)J=14.5 Hz), 14.5 (d, ^(PC)J=37.7 Hz), 12.3; ³¹P{¹H} NMR (202.5 MHz, CD₃CN) δ [ppm] 39.8.

EtFluP(nButBu)—HBF₄ (28a)

9-Ethylfluorene (41) (5.85 g, 30.0 mmol) was dissolved in THF, abs (50 ml), treated with n-BuLi (11.5 ml, 2.5 M in hexane, 29.0 mmol) at −30° C. and stirred for 1 h at ambient temperature. Then tBuPCl₂ (4.36 g, 27.4 mmol) dissolved in THF, abs (50 ml) was added at −80° C. to the red solution. The reaction mixture was stirred at ambient temperature for 14 h and the color turned slightly greenish. Completeness of the conversion was checked by ³¹P NMR which showed one single signal at 162.91 ppm (in benzene) for EtFluPtBuCl. At −30° C. n-BuLi (14.0 ml, 2.5 M in hexane, 35.0 mmol) was added and the reaction mixture stirred at ambient temperature overnight. The suspension was filtered over a small pad of Celite® using Schlenk technique. The clear reddish filtrate was treated with HBF₄.Et₂O (5.2 ml, 38 mmol). The volatiles were removed in vacuo to give a yellow residue, which was extracted with chloroform (6 ml), filtered and the clear filtrate added dropwise into Et₂O (200 ml, vigorously stirred) to precipitate the product. Filtration and removal of the volatiles in vacuo afforded 28a (5.3 g, 45%) as a white solid.

¹H NMR (500 MHz, CDCl₃) δ [ppm] 7.95 (d, ³J=6.5 Hz, 1H, ar), 7.89-7.84 (m, 2H, ar), 7.72 (d, ³J=8 Hz, 1H, ar), 7.60-7.49 (m, 4H, ar), 6.77 (d, ¹J=481 Hz 1H, PH), 2.81-2.73 (m, 1H, CH₂ (ethyl)), 2.69-2.61 (m, 1H, CH₂ (ethyl)), 2.42-2.32 (m, 1H, CH₂ (butyl)), 2.18-2.08 (m, 1H, CH₂ (butyl)), 1.88-1.77 (m, 2H, CH₂ (butyl)), 1.57-1.43 (m, 2 H, CH₂ (butyl)), 0.97 (t, ³J=7.5 Hz, 3H, (butyl)), 0.85 (d, ³J(PH)=17 Hz, 9H, CH₃), 0.32 (t, ³J=7.5 Hz, 3H, (ethyl)); ¹³C{¹H} NMR (125.75 MHz, CDCl₃) δ [ppm] 141.7 (d, ^(PC)J=4.4 Hz), 141.3 (d, ^(PC)J=4.5 Hz), 139.9, 139.0 (d, ^(PC)J=2.8 Hz), 130.4, 130.2, 129.3, 128.9, 125.9 (d, ^(PC)J=3.3 Hz), 124.7 (d, ^(PC)J=2.3 Hz), 121.4, 121.0, 52.2 (d, ^(PC)J=34 Hz), 33.7 (d, ^(PC)J=36.3 Hz), 28.8 (d, ^(PC)J=5.5 Hz), 28.1, 26.5, 24.1 (d, ^(PC)J=13.1 Hz), 15.0 (d, ^(PC)J=37.7 Hz), 13.2, 6.3 (d, ^(PC)J=9.3 Hz); ³¹P{¹H} NMR (202.45 MHz, CDCl₃) δ [ppm] 39.4; ³¹P NMR (202.45 MHz, CDCl₃) δ [ppm] 39.4 (d, ^(PC)J=480 Hz).

(v) Preparation of a Monosulfonated Fluorenylphosphine 9-Et-2-SO₃H-FluPCy₂.HBF₄ (13a)

To a solution of EtFluPCy₂ HBF₄ (9a) (2.35 g, 4.92 mmol) in 1 ml of CH₂Cl₂, abs, 2.3 ml of concentrated sulfuric acid were added at 0° C. After stirring the solution at 40° C. overnight, 5 g of ice were added. The reaction mixture was extracted with chloroform (3×10 ml). The combined organic layers were dried over MgSO₄. After filtration the clear filtrate was reduced to a final volume of 5 ml in vacuo. The concentrate was added dropwise to diethylether (500 ml, vigorously stirred) to precipitate the product. Filtration and removal of the volatiles in vacuo afforded the pure product 13a (1.8 g, 67%) as a white solid.

¹H NMR (500 MHz, methanol-d₄) δ [ppm] 8.22 (s, 1H, ar), 8.10 (s, 2H, ar), 8.09 (s, 1H, ar), 7.86 (d, ³J=10 Hz, 1H, ar), 7.68 (t, ³J=7.5 Hz, 1H, ar), 7.60 (t, ³J=7.5 Hz, 1H, ar), 2.87-2.81 (m, 1H, CM), 2.79-2.74 (m, 1H, CH₂), 2.69-2.61 (m, 1H, CH), 2.51-2.46 (m, 1H, CH), 2.05-1.05 (m, 20H, CH₂), 0.34 (t, 3J=6.5 Hz, 3H, CM). ¹³C{¹H} NMR (125.75 MHz, methanol-d₄) δ [ppm] 147.5, 144.8 (d, ^(PC)J=4.8 Hz), 142.5 (d, ^(PC)J=4.5 Hz), 141.8 (d, ^(PC)J=2.9 Hz), 141.0 (d, ^(PC)J=2.0 Hz), 131.8, 130.6, 129.4, 126.4 (d, ^(PC)J=4.0 Hz), 124.0 (d, ^(PC)J=3.9 Hz), 123.2, 122.4, 53.9 (d, ^(PC)J=33.7 Hz), 32.4 (d, ^(PC)J=9.2 Hz), 32.1 (d, ^(PC)J=8.7 Hz), 30.8 (d, ^(PC)J=3.8 Hz), 30.4 (d, ^(PC)J=3.4 Hz), 29.6 (d, ^(PC)J=4.0 Hz), 29.5 (d, ^(PC)J=5.4 Hz), 28.9 (d, ^(PC)J=3.8 Hz), 28.5, 27.7 (d, ^(PC)J=4.9 Hz), 27.6 (d, ^(PC)J=4.3 Hz), 27.4 (d, ^(PC)J=11.3 Hz), 27.2 (d, ^(PC)J=11.9 Hz), 26.0 (d, ^(PC)J=2.8 Hz), 6.9 (d, ^(PC)J=11.7 Hz). ³¹P{¹H} NMR (202.46 MHz, methanol-d₄) δ [ppm] 34.9.

B. USE OF PHOSPHINE COMPOUNDS IN CROSS COUPLING REACTIONS

Some of the synthesized phosphine compounds were used as ligands in Pd complexes performing as catalysts in various cross-coupling reactions. All cross-coupling reaction were carried out under an argon atmosphere in degassed solvents (freeze and thaw). TON means catalytic turnover number and is defined as the ratio of the number of moles of product to the number of moles of catalyst.

I. Sonogoshira Coupling Reactions (i) Sonogashira Coupling of Aryl Bromides (in Diisopropylamine)

Dry diisopropylamine (10 ml), arylbromide (10 mmol) and acetylene (11 mmol) were placed in a Schlenk tube. Then the catalyst was added in the given concentration as a ready-made mixture of Na₂PdCl₄/ligand (phosphonium salt)/CuI (4:8:3) under argon. Unless otherwise noted the reaction mixture was stirred at 50° C. in an aluminum block. After cooling to room temperature the reaction mixture was diluted with ether (15 ml), washed with water (10 ml), the organic phase dried over MgSO₄, filtered and concentrated in vacuo. The product was isolated by column chromatography (silica, cyclohexane/ethylacetate (100:2). Alternatively the yield was either determined via gas chromatography with hexadecane or diethylene glycol di-n-butylether as an internal standard or by determination of the mass of the isolated iPr₂NH₂ ⁺Br⁻.

TABLE 1 Primary Sonogashira screen for the reaction of phenylacetylene and 4-bromotoluene utilizing various phosphine compounds Ligand TON^([a]) C₁₈H₃₇FluPCy₂ (11) 5900 EtFluPCy₂ (9a) 5600 MeFluPCy₂ (8a) 5600 C₁₈H₃₇FluPiPr₂ (7a) 5500 Ad₂PBn* 3600 MeFluPiPr₂ (5a) 3500 EtFluPiPr₂ (6a) 3200 9-Et-1-MeFluPCy₂ (12a) 2600 iPrFluPCy₂ (22a) 906 Et-1,3,8-Me₃FluPCy₂ (29a) 850 iPrFluPiPr₂ (23a) 500 HFluPtBu₂ (25a) 330 PhFluPiPr₂ (30a) 250

Reagents and conditions: 10 mmol 4-bromotoluene, 11 mmol phenylacetylene, 10 ml iPr₂NH, 50° C., 24 h. Catalyst: Na₂PdCl₄/ligand/CuI (4:8:3), catalyst mixture in iPr₂NH₂Br, max. TON=15000.

[a] Average of two runs. Determined by the mass of the isolated ammonia salt.

Comparative Example

Ad₂PBn is an adamantly-substituted phosphine and is available under the trademark cataCXium® A from Degussa AG.

TABLE 2 Sonogashira coupling of various aryl bromides with phenylacetylene using EtFluPCy₂•HBF₄ (9a) (9a)

Aryl Run bromide Product t (h) Yield^([a]) 1 4- bromoace- tophenone

 3 ≧99 2 4- bromo- anisol

24 ≧99 3 4-bromo- imethyl- aniline

24 ≧99 4 4- bromo- toluene

24 ≧99 5 2- bromo- toluene

24  95

Reagents and conditions: 10 mmol aryl bromide, 11 mmol phenylacetylene, 10 ml iPr₂NH, 50° C., 24 h. Catalyst: 0.02 mol % Na₂PdCl₄, 0.04 mol % EtFluPCy₂.HBF₄ (9a), 0.015 mol % CuI, catalyst mixture in iPr₂NH₂Br.

[a] Average of two runs, determined by GC (hexadecane as internal standard) and by the mass of the isolated ammonium salt. Both analytical methods gave similar results.

TABLE 3 Sonogashira-coupling of aryl bromides. Determination of TON using various phosphine ligands Aryl Li- mol % t Run bromide Acetylene gand^([a]) Pd (h) Yield^([b]) TON 1 bromo- phenyl- 5 0.0033 16 81% 24300 benzene acetylene 2 bromo- phenyl- 6 0.0033 16 88% 26400 benzene acetylene 3 2-bromo- phenyl- 5 0.0033 16 83% 24900 toluene acetylene 4 2-bromo- phenyl- 5 0.0067 16 57% 8550 m-xylene acetylene 5 2-bromo- phenyl- 6 0.0033 16 51% 15300 benzotri- acetylene fluoride 6 4-bromo- phenyl- 5 0.0033 20 41% 23300 anisol acetylene 7 4-bromo- phenyl- 6 0.0033 20 84% 25200 anisol acetylene Reagents and conditions: 10 mmol aryl bromide, 11 mmol acetylene, 10 ml HNiPr₂, 80° C., 24 h. Catalyst: Na₂PdCl₄/phosphonium salt/CuI (4:8:3), catalyst mixture in iPr₂NH•HBr. ^([a])5: MeFluPiPr₂; 6: EtFluPiPr₂ ^([b])Average of 2 runs.

(ii) Sonogashira Coupling of Aryl Chlorides (in DMSO)

Dry DMSO (5 ml, crown cap), aryl chloride (1.5 mmol), acetylene (2.1 mmol) and Na₂CO₃ (3 mmol) were placed in a Schlenk tube. Then the catalyst was added in the given concentration, Na₂PdCl₄/ligand (phosphonium salt)/CuI (4:8:3) under argon. The reaction mixture was stirred at 100-120° C. in an aluminum block for 12 to 20 h. After cooling to room temperature the reaction mixture was diluted with ether (15 ml), washed with water (10 ml), the organic phase dried over MgSO₄, filtered and concentrated in vacuo. The product was isolated by column chromatography (silica, cyclohexane/ethylacetate (100:2). Alternatively the yield was determined via gaschromatography with hexadecane or diethylene glycol di-n-butylether as an internal standard.

TABLE 4 Sonogashira reactions with aryl chlorides

Run Aryl chloride T (° C.) t (h) yield^([a]) 1 4-chloroanisol 110 16 h 43% 44%^([b]) 47%^([c]) 23%^([d]) 2 4-nitrochlorobenzene 100 12 88% 3 4-chloroacetophenone 100 12 94% 4 4-CF₃-chlorobenzene 100 12 92% 5 chlorobenzene 120 16 87% 6 4-chlorotoluene 120 16 91% 7 4-chloroanisol 120 20 73% Reagents and conditions: 1.5 mmol aryl chloride, 2.1 mmol phenylacetylene, 3 mmol Na₂CO₃, 5 ml DMSO, catalyst: 1 mol % Na₂PdCl₄/ligand/CuI (4:8:3). phosphonium salt: MeFluiPr₂ · HBF₄ (5a). Reaction conditions not been optimized. ^([a])Average of two runs. Purified by chromatography through a short silica pad. Eluent: cyclohexane:ethylacetate (10:1). ^([b])ligand: EtFluPCy₂ (9a) ^([c])ligand: BnFluPCy₂ (10a). ^([d])ligand: Ad₂PBn (comparative example)

(iii) Sonogashira Coupling of Aryl Bromides (in Water)

Preparation of the catalyst stock solution: Na₂PdCl₄ (0.05 mmol), 9-Et-2-SO₃HFlu-PCy₂.HBF₄ (13a) (0.1 mmol) and Cs₂CO₃ (0.4 mmol) were placed in a Schlenk tube under argon. Degassed water (5.0 ml) was added and the mixture was stirred at 45° C. for 2 h until the solution turns off white. The stock solution has a concentration of 1 mol %/(ml mmol aryl halide).

Cross-coupling reaction: The arylbromide (1 mmol), acetylene (1.1 mmol) and Cs₂CO₃ (2 mmol) were charged into a in Schlenk tube and water (2 ml) and isopropanol (2 ml) as well as the catalyst stock solution were added. The reaction mixture was stirred at 100° C. in an aluminum block for 1.5 to 4 h. After cooling to room temperature the reaction mixture was diluted with ether (15 ml), washed with water (10 ml), the organic phase was dried over MgSO₄, filtered and concentrated in vacuo. The product was isolated by column chromatography (silica, cyclohexane/ethylacetate (100:2). Alternatively the yield was determined via gaschromatography with hexadecane or diethylene glycol di-n-butylether as an internal standard.

TABLE 5 Sonogashira reaction of aryl bromides in an aqueous system Conver- Run Aryl bromide Acetylene Product t (h) sion^([a]) Yield^([b]) 1

1 h ≧99% 97% 2

1.5 h ≧99% 98% 3

2 h ≧99% 95% 4

4 h ≧99% 95% 5

4 h ≧99% 94% 6

4 h ≧99% 95% Reagents and conditions: 1 mmol aryl bromide, 1.2 mmol acetylene, 1.5 mmol Cs₂CO₃, 1 mol % Na₂PdCl₄, 2 mol % ligand ((9-ethyl-2-sulfofluorenyl)dicyclohexyl-phosphonium-tetrafluoroborate; 9-Et-2-SO₃HFluPCy₂ (13)), H2O/i-propanol (4 ml, 1:1), 100° C. Reaction times and temperatures were not optimized. ^([a]) Average of 2 runs, determined by GC using hexadecane as internal standard. ^([b]) Average of 2 runs. Purified by chromatography, eluents: cyclohexane:ethylacetate (10:1).

II. Suzuki Coupling Reactions (i) Suzuki Reaction of Aryl Halides (in Dioxane)

Preparation of the catalyst stock solution: Na₂PdCl₄ (0.05 mmol), phosphonium salt (0.1 mmol) and Cs₂CO₃ (0.2 mmol) were placed in a Schlenk tube. Dioxane (5.0 ml) was added and the mixture was stirred at 45° C. for 2 h until the solution turns off white. The so prepared stock solution has a concentration of 1 mol %/(ml*mmol aryl halide).

Cross-coupling reaction: Dioxane (5 ml) and the catalyst stock solution were added to the aryl halide (1 mmol), boronic acid (1.5 mmol) and Cs₂CO₃ (2 mmol). The reaction mixture was stirred at 100° C. in an aluminum block. After cooling to room temperature the reaction mixture was diluted with ether (15 ml), washed with water (10 ml), the organic phase was dried over MgSO₄, filtered and concentrated in vacuo. The product was isolated by column chromatography (silica, cyclohexane/ethylacetate (100:2). Alternatively the yield was determined via gaschromatography with hexadecane or diethylene glycol di-n-butylether as an internal standard.

TABLE 6 Suzuki reaction with aryl chlorides, ligand-screening

mol % Conver- Run Ligand catalyst^([a]) sion^([b]) 1 EtFluPCy₂ (9) 0.5 77% 2 BnFluPCy₂ (10) 0.5 13% 3 iPrFluPCy₂ (22) 0.5  5% 4 MeFluPiPr₂ (5) 0.5 21% Reagents and conditions: 1 mmol aryl chloride, 1.5 boronic acid, 2.0 mmol Cs₂CO₃, dioxane (5 ml), 80° C., 12 h. ^([a])Na₂PdCl₄/ligand (1:2) ^([b])Average of 2 runs, determined by GC using hexadecane as internal standard.

TABLE 7 Suzuki reaction with aryl chlorides using EtFluPCy₂ · HBF₄ (9a) and BnFluPiPr₂ · HBF₄ (26a)

mol % Conver- Run Aryl chloride Boronic acid Product Ligand^([a]) catalyst^([b]) t(h) sion^([c]) 1

9 0.5 0.05  2 h 24 h ≧99% ≧99% 2

9 0.5 0.05  2 h 24 h ≧99% ≧99% 3

9 0.5 0.05  2 h 24 h ≧99% ≧99% 4

9 0.5 0.1 0.05  5 h 20 h 24 h ≧99% ≧99%   65% 5

9 0.5 0.05  5 h 24 h ≧99% ≧99% 6

26 1 0.1  1 h 12 h ≧99% ≧99% 7

26 1 0.1 1.5 h  12 h ≧99% ≧99% 8

26 1 0.1 1.5 h  12 h ≧99% ≧99% 9

26 1 0.3 0.1  4 h 12 h 12 h ≧99% ≧99%   81% 10

26 1 0.2  4   12   ≧99% ≧99% Reagents and conditions: 1 mmol aryl chloride, 1.5 boronic acid, 2.0 mmol Cs₂CO₃, dioxane (5 ml), 100° C., reaction conditions and the amount of catalyst have not been optimized. ^([a])ligand: 9: EtFluPCy₂; 26: BnFluPiPr₂ ^([b])catalyst: Na₂PdC1₄/ligand (1:2) ^([c])Average of two runs, determined by GC using hexadecane as internal standard.

(ii) Suzuki Reaction of Aryl Halides (in Water)

Preparation of the catalyst-stock-solution: The catalyst stock solution was prepared as described for the aqueous Sonogshira reaction using 9-Et-2-SO₃HFlu-PCy₂.HBF₄ (13a).

Cross-coupling reaction: Aryl halide (1 mmol), boronic acid (1.2 mmol) and K₂CO₃ (3.2 mmol) were first added to water (4 ml), then the catalyst stock solution and two drops of Labrasol® (caprylocaproyl macrogol-8 glyceride blend, saturated polyglycolized glycerides consisting of mono-, di- and triglycerides of mono- and di-fatty acids of polyethylene glycol (PEG)) were added. The reaction mixture was stirred at the respective temperatures (see Table 8) for 0.5-20 h (see Table 8). After cooling to room temperature the reaction mixture was diluted with ether (15 ml), washed with water (10 ml), the organic phase was dried over MgSO₄, filtered and concentrated in vacuo. The product was isolated by column chromatography (silica, cyclohexane/ethylacetate (100:2). Alternatively the yield was determined via gas chromatography with hexadecane or diethylene glycol di-n-butylether as an internal standard.

TABLE 8 Suzuki coupling of aryl bromides and aryl chlorides in water Pd Condi- Yield Run Halide Boronic acid Product [mol %] tions [%]^([f]) 1

0.1 0.01   0.005 RT, 20 h 100° C., 2 h 100° C., 3.5 h ≧99% ≧99%   ≧99% 2

0.5   0.5 90° C., 45 min 90° C., 30 min^([a]) ≧99%   ≧99% 3

0.5 50° C., 1.5 h ≧99% 4

0.5 50° C., 4 h ≧99% 5

0.5 50° C., 1.5 h ≧99% 6

1 RT, 20 h ≧99% 7

0.25 0.1   0.1 RT, 3 h RT, 2.5 h RT, 2.5 h^([a]) ≧99%   50%     66% 8

1 100° C., 20 h ≧99% 9

0.5 65° C., 20 h ≧99% 10

1 90° C., 20 h ≧99% 11

0.05   0.1   1   1   0.1   0.1   0.1   0.1 100° C., 2 h 100° C., 30 min 40° C., 10 h RT, 20 h^([a]) 100° C., 45 min^([b]) 100° C., 1 h^([c]) 100° C., 1 h^([d]) 100° C., 25 min^([e]) ≧99%   ≧99%   ≧99%   ≧99%   ≧99%   ≧99%   ≧99%   ≧99%   12

0.5   0.5 90° C., 4 h 90° C., 4 h^([a])   92%     98% 13

0.5   1 100° C., 2 h RT, 20 h^([a]) ≧99%   ≧99% 14

0.5   1 100° C., 2.5 h^([a]) RT, 20 h^([a]) ≧99%   ≧99% 15

0.5 100° C., 90 min ≧99% 16

1 100° C., 24 h ≧99% 7

1   0.5 90° C., 30 min RT, 4 h ≧99%   ≧99% 18

0.5 90° C., 20 h   74% 19

0.5 65° C., 20 h   80% 20

0.5 90° C., 20 h ≧99% 21

0.5 100° C., 12 h^([a]) ≧99% 22

0.5 100° C., 12 h^([a]) ≧99% 23

0.5 100° C., 12 h^([a]) ≧99% 24

0.1 100° C., 12 h^([a]) ≧99% 25

0.5 100° C., 12 h^([a]) ≧99% 26

0.1 100° C., 12 h^([a]) ≧99% 27

0.5 100° C., 12 h^([a]) ≧99% 28

0.5   0.1 100° C., 20 h^([a]) 100° C., 20 h^([a]) ≧99%     43% 29

1 100° C., 24 h^([a])   97 30

1 100° C., 24 h^([a])   96 31

0.5 100° C., 24 h^([a])   90 General reaction conditions: 1.0 equiv. aryl halide, 1.2 equiv. boronic acid, 3.2 equiv. K₂CO₃, degassed water (4 ml mmol⁻¹), catalyst: Na₂PdCl₄/ligand (1:2), ligand: 9-Et-2-SO₃HFluPCy₂ (13). Reaction times and temperatures were not optimized. ^([a]) Additive: Labrasol (0.05 ml). ^([b]) 1 equiv. aryl halide, 1.2 equiv. boronic acid, 3.2 equiv. CsCO₃. ^([c]) 1 equiv. aryl halide, 1.2 equiv. boronic acid, 3.2 equiv. KF. ^([d]) 1 equiv. aryl halide, 1.2 equiv. boronic acid, 3.2 equiv. NaOH. ^([e]) 1 equiv. aryl halide, 1.2 equiv. boronic acid, 3.2 equiv. K₃PO₄. ^([f]) Average of two runs, determined by GC using hexadecane as internal standard.

III. Buchwald-Hartwig Amination of Aryl Halides

5 ml dry toluene, 5 mmol aryl halide, 6 mmol amine and 6 mmol NaOtBu were placed in a Schlenk tube. Next the catalyst Na₂PdCl₄/EtFluPCy₂ (9) (as phosphonium salt (9a)) (1:2) was added in the given concentration. The reaction mixture was stirred at 120° C. in an aluminum block. After cooling to room temperature the reaction mixture was diluted with ether (15 ml), washed with water (10 ml), the organic phase dried over MgSO₄, filtered and concentrated in vacuo. The product was isolated by column chromatography (silica, cyclohexane/ethylacetate (90:10). Alternatively the yield was determined via gaschromatography with hexadecane or diethylene glycol di-n-butylether as an internal standard.

TABLE 9 Buchwald-Hartwig amination of aryl bromides and chlorides.

mol % Conver- Entry Aryl halide Amine Product catalyst t (h) sion^([a]) 1

0.5 12   16% 2

0.1 3 ≧99% 3

0.5 2 ≧99% 4

0.5 2 ≧99% 5

0.5 6   91% 6

0.25 2 ≧99% 7

0.5 2 ≧99% 8

0.5 12 ≧99% 9

0.5 12 ≧99% 10

0.5 12   48%

Reagents and conditions: 5 ml toluene, 5 mmol aryl halide, 6 mmol amine, 6 mmol NaOtBu, Pd(OAc)₂/ligand (1:2),

phosphonium salt: EtFluPCy₂.HBF₄ (9a), 120° C., reaction conditions have not been optimized.

[a] Average of two runs, determined by GC using hexadecane as internal standard.

IV. Carbonylation Reactions (i) Alkoxycarbonylation Reactions of Different Aryl Bromides Using Different Phosphonium Salts

0.0025 mmol Pd(OAc)₂, 0.0075 mmol ligand (phosphonium salt) and 0.385 mmol TMEDA were diluted with n-butanol to a total volume of 10 ml. 0.5 mmol of each substrate was introduced directly in the autoclaves, and then 1 ml of the catalyst solution was added to the autoclave. After purging with carbon monoxide the pressure was set to 25 bar CO and the autoclave was stirred while warming up to 115° C. The reactions were hold at 115° C. for 20 h. After cooling down and releasing the pressure the raw mixtures were filtered through a short path of Al₂O₃ and the conversion was determined via GC.

TABLE 10 Carbonylation reactions of aryl bromides in n-butanol

Conver- Run Ligand Substrate sion (%) 1 MeFluPCy₂ (8) Ethyl 4- 95 bromobenzoate 2 MeFluPiPr₂ (5) Ethyl 4- 97 bromobenzoate 3 EtFluPiPr₂ (6) Ethyl 4- 95 bromobenzoate 4 EtFluPCy₂ (9) Ethyl 4- 97 bromobenzoate 5 iPrFluPiPr₂ (23) Ethyl 4- 80 bromobenzoate 6 iPrFluPCy₂ (22) Ethyl 4- 92 bromobenzoate 7 Cp*PCy₂ (14) Ethyl 4- 14 bromobenzoate 8 C₁₈H₂₇FluPCy₂ (11) Ethyl 4- 34 bromobenzoate 9 EtFluP(nButBu) Ethyl 4- 31 (28) bromobenzoate 10 EtMeFluPCy₂ (12) Ethyl 4- 18 bromobenzoate 11 Me₃InPCy₂ (16) 3-Br-Acetophenone 66 12 Me₃InPCy₂ (16) 4-Br-Acetophenone 85 13 Me₃InPCy₂ (16) 2-Br-Benzonitrile 94 14 Me₃InPCy₂ (16) 2-Br-Pyridine 99 15 Me₃InPCy₂ (16) 2-Br-Thiophene 82 16 BnFluPCy₂ (10) 4-Br-2Cl-Toluene 75 17 BnFluPCy₂ (10) 3-Br-Anisol 65 18 BnFluPCy₂ (10) 3-Br-Acetophenone 95 19 BnFluPCy₂ (10) 4-Br-Acetophenone 95 20 BnFluPCy₂ (10) 2-Br-Benzonitrile 98 21 BnFluPCy₂ (10) 3-Br-Pyridine 98 22 BnFluPCy₂ (10) 2-Br-Pyridine 100 23 BnFluPCy₂ (10) 2-Br-Thiophene 62 24 BnFluPCy₂ (10) 3-Br-Thianaphtene 78 25 Me₃InPiPr₂ (17) 2-Br-Benzonitrile 90 26 Me₃InPiPr₂ (17) 2-Br-Pyridine 98 27 Me₃InPiPr₂ (17) 2-Br-Thiophene 82 28 Me₅InPiPr₂ (19) 2-Br-Pyridine 67 29 Me₅InPCy₂ (18) 2-Br-Pyridine 74 30 Cp*PiPr₂ (15) 2-Br-Pyridine 60

(ii) Reductive Carbonylation of Ethyl 4-Bromobenzoate Using Different Phosphonium Salts

0.0025 mmol Pd(OAc)₂, 0.0075 mmol ligand (phosphonium salts) and 0.385 mmol TMEDA were diluted in toluene to a total volume of 10 ml. 0.5 mmol of ethyl 4-bromobenzoate was introduced directly in the autoclaves, and then 1 ml of the catalyst solution was added to the autoclave. After purging with synthesis gas (CO/H₂ 1:1), the pressure was set to 25 bar CO/H₂ and the autoclave was stirred while warming up to 115° C. The reactions were hold at 115° C. for 20 h. After cooling down and releasing the pressure the raw mixtures were filtered through a short path of Al₂O₃ and the conversion was determined via GC.

TABLE 11 Reductive carbonylation reactions of ethyl 4-bromobenzoate.

Run Ligand Conversion (%) 1 MeFluPCy₂ (8) 83 2 MeFluPiPr₂ (5) 18 3 EtFluPiPr₂ (6) 30 4 EtFluPCy₂ (9) 34 5 iPrFluPCy₂ (22) 16 6 Cp*PCy₂ (14) 30 7 C₁₈H₃₇FluPCy₂ (11) 38 8 EtFluP (nButBu) (28) 38 9 EtMeFluPCy₂ (12) 13 

1-38. (canceled)
 39. A phosphine compound represented by the general formula (4):

or its corresponding phosphonium salt represented by the general formula (4a):

wherein R′ and R″ are each independently selected from alkyl, cycloalkyl and 2-furyl radicals, or R′ and R″ are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon-phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group consisting of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-octadecyl, benzyl, and phenyl radicals that are unsubstituted; R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ are each independently selected from the group consisting of H; aliphatic, heteroaliphatic, aromatic, alicyclic, heterocyclic radicals, heteroatom-containing radicals comprising an aromatic, alicyclic, or heterocyclic radical and an additional heteroatom linking the aromatic, alicyclic, or heterocyclic radical atom with the carbon atom of the fluorenyl group, all the foregoing radicals being unsubstituted or substituted by further carbon and/or heteroatoms; halogens; and heteroatom-containing groups; or adjacent groups selected from R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ together form a divalent radical thereby forming a fused ring system; and Y⁻ represents an anion.
 40. The phosphine compound or its corresponding phosphonium salt according to claim 39, wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ independently are selected from the group consisting of H, alkyl, cycloalkyl, aryl, and alkoxy radicals that are unsubstituted or substituted; halogens, and heteroatom-containing groups imparting water-solubility.
 41. The phosphine compound or its corresponding phosphonium salt according to claim 40, wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ independently are selected from the group consisting of H, a methyl radical, a methoxy radical, and —SO₃H.
 42. The phosphine compound or its corresponding phosphonium salt according to claim 40, wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ are hydrogen.
 43. The phosphine compound or its corresponding phosphonium salt according to claim 39, wherein R is (a) an unbranched alkyl radical or a benzyl radical, or (b) a methyl or ethyl radical.
 44. The phosphine compound or its corresponding phosphonium salt according to claim 39, wherein R′ and R″ are (a) each independently selected from the group consisting of isopropyl, n-butyl, t-butyl, neopentyl, cyclohexyl, and adamantyl radicals, (b) each independently selected from the group consisting of isopropyl and cyclohexyl radicals (c) joined together to form a [3.3.1]- or [4.2.1]-phobyl radical with the phosphorous atom, or (d) the same radicals.
 45. The phosphine compound or its corresponding phosphonium salt according to claim 39 which is selected from the group consisting of: (9-methylfluoren-9-yl)diisopropylphosphine (9-MeFluPiPr₂) (5),

(9-ethylfluoren-9-yl)diisopropylphosphine (9-EtFluPiPr₂) (6),

(9-benzylfluoren-9-yl)diisopropylphosphine (9-BnFluPiPr₂) (26),

(9-octadecylfluoren-9-yl)diisopropylphosphine (9-C₁₈H₃₇FluPiPr₂) (7),

(9-methylfluoren-9-yl)dicyclohexylphosphine (9-MeFluPCy₂) (8),

(9-ethylfluoren-9-yl)dicyclohexylphosphine (9-EtFluPCy₂) (9),

(9-benzylfluoren-9-yl)dicyclohexylphosphine (9-BnFluPCy₂) (10),

(9-octadecylfluoren-9-yl)dicyclohexylphosphine (9-C₁₈H₃₇FluPCy₂) (11),

(1-methyl-9-ethylfluoren-9-yl)dicyclohexylphosphine (9-Et-1-MeFluPCy₂) (12),

(9-ethyl-2-sulfofluoren-9-yl)dicyclohexylphosphine (2-SO₃H-9-EtFluPCy₂) (13),

and their corresponding phosphonium salts 9-MeFluPiPr₂.H⁺Y⁻ (5a), 9-EtFluPiPr₂.H⁺Y⁻ (6a), 9-BnFluPiPr₂.H⁺Y⁻ (26a), 9-C₁₈H₃₇FluPiPr₂.H⁺Y⁻ (7a), 9-MeFluPCy₂.H⁺Y⁻ (8a), 9-EtFluPCy₂.H⁺Y⁻ (9a), 9-BnFluPCy₂.H⁺Y⁻ (10a), 9-C₁₈H₃₇FluPCy₂.H⁺Y⁻ (11a), 9-Et-1-MeFluPCy₂.H⁺Y⁻ (12a), and 9-Et-2-SO₃HFluPCy₂.H⁺Y⁻ (13a), wherein Flu represents a fluoren-9-yl radical, Me represents a methyl radical, Et represents an ethyl radical, Bn represents a benzyl radical, iPr represents an isopropyl radical, and Cy represents a cyclohexyl radical.
 46. The phosphonium salt according to claim 39, wherein Y⁻ is BF₄ ⁻.
 47. A coordination compound comprising (i) a phosphine compound according to claim 39; and (ii) a transition metal selected from Groups 8, 9, 10, and 11 of the Periodic Table of the Elements.
 48. The coordination compound according to claim 47, wherein the transition metal is selected from the group consisting of Pd, Ni, Pt, Rh, Ir, Ru, Co, Fe, Cu, and Au.
 49. The coordination compound according to claim 47, wherein the transition metal is Pd or Ni.
 50. A method for preparing an organic compound which comprises using a phosphine compound or a phosphonium salt according to claim 39 in combination with a transition metal as a catalyst or as a part of a catalyst system that is used to prepare the organic compound, wherein the transition metal is from Groups 8, 9, 10, and 11 of the Periodic Table of the Elements.
 51. The method according to claim 50, wherein the phosphine compound or the phosphonium salt is used in combination with the transition metal as a coordination compound.
 52. The method according to claim 50, wherein the preparation of the organic compound includes the formation of a C—C bond or C-heteroatom bond.
 53. The method according to claim 50, wherein the transition metal is Pd and the preparation of the organic compound includes the formation of a C—C bond and a reaction selected from the group consisting of: Suzuki cross-coupling of organoboron compounds with aryl, heteroaryl or vinyl halides or pseudohalides; Stille cross-coupling of organotin compounds with carbon electrophiles comprising a halogen or pseudohalogen as leaving group; Hiyama cross-coupling of organosilanes with aryl, heteroaryl or vinyl halides or pseudohalides; Negishi cross-coupling of organozinc compounds with aryl, heteroaryl or vinyl halides or pseudohalides; Kumada cross-coupling of Grignard compounds with aryl, heteroaryl or vinyl halides or pseudohalides; Sonogashira cross-coupling of terminal alkynes with aryl, heteroaryl or vinyl halides or pseudohalides; α-arylation of enolates and other stabilized carbanions with aryl or heteroaryl halides or pseudohalides; cyanation of aryl or heteroaryl halides or pseudohalides; carbonylation of aryl or heteroaryl halides or pseudohalides; and Heck coupling of aryl, heteroaryl or vinyl halides or pseudohalides to olefins.
 54. The method according to claim 50, wherein the transition metal is Pd and the preparation of the organic compound includes (a) the formation of a C—N bond and Buchwald-Hartwig coupling of an aryl or heteroaryl halide or pseudohalide with an amine (Buchwald-Hartwig amination), or (b) the formation of a C—O bond and coupling of an aryl or heteroaryl halide or pseudohalide with an alcohol.
 55. The method according to claim 50, wherein the organic compound is prepared by hydrodehalogenation of an aryl or heteroaryl halide.
 56. The method according to claim 53, wherein the pseudohalogen or pseudohalide is selected from the group consisting of —COCl, —SO₂Cl, —N₂X, —OP(O)(OR)₂, triflate, and tosylate.
 57. The method according to claim 53, wherein the pseudohalogen or pseudohalide is triflate.
 58. The method according to claim 53, wherein the halogen or halide is —Cl or —Br.
 59. A process for the preparation of a phosphine compound according to claim 39, which comprises (a) deprotonating a substituted or unsubstituted fluorene by the use of a strong base, and (b) reacting the resulting anion with (1) a phosphinous halide according to the formula R′R″PX, wherein X is Cl or Br, or (2) a phosphonous dihalide according to the formula R′PX₂, wherein X is Cl or Br, to form the phosphinous halide, and alkylating the phosphinous halide with an appropriate organometallic alkylation agent to introduce the R″ group, to form the phosphine compound.
 60. A process for the preparation of a phosphonium salt according to claim 39, which comprises preparing a phosphine compound as described in claim 39 and converting the phosphine compound to its corresponding phosphonium salt by reacting with H⁺Y⁻. 